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1zwm

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{{STRUCTURE_1zwm| PDB=1zwm | SCENE= }}
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'''NMR structure of murine gamma-S crystallin'''
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===NMR structure of murine gamma-S crystallin===
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==Overview==
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The solution structure of murine gammaS-crystallin (gammaS) has been determined by multidimensional triple resonance NMR spectroscopy, using restraints derived from two sets of dipolar couplings, recorded in different alignment media, and supplemented by a small number of NOE distance restraints. gammaS consists of two topologically similar domains, arranged with an approximate twofold symmetry, and each domain shows close structural homology to closely related (approximately 50% sequence identity) domains found in other members of the gamma-crystallin family. Each domain consists of two four-strand "Greek key" beta-sheets. Although the domains are tightly anchored to one another by the hydrophobic surfaces of the two inner Greek key motifs, the N-arm, the interdomain linker and several turn regions show unexpected flexibility and disorder in solution. This may contribute entropic stabilization to the protein in solution, but may also indicate nucleation sites for unfolding or other structural transitions. The method used for solving the gammaS structure relies on the recently introduced molecular fragment replacement method, which capitalizes on the large database of protein structures previously solved by X-ray crystallography and NMR.
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{{ABSTRACT_PUBMED_16260758}}
==About this Structure==
==About this Structure==
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1ZWM is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZWM OCA].
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1ZWM is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZWM OCA].
==Reference==
==Reference==
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[[Category: Relaxation]]
[[Category: Relaxation]]
[[Category: Residual dipolar coupling]]
[[Category: Residual dipolar coupling]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 15:17:24 2008''

Revision as of 12:17, 28 July 2008

Image:1zwm.png

Template:STRUCTURE 1zwm

NMR structure of murine gamma-S crystallin

Template:ABSTRACT PUBMED 16260758

About this Structure

1ZWM is a Single protein structure of sequence from Mus musculus. Full experimental information is available from OCA.

Reference

Solution structure of (gamma)S-crystallin by molecular fragment replacement NMR., Wu Z, Delaglio F, Wyatt K, Wistow G, Bax A, Protein Sci. 2005 Dec;14(12):3101-14. Epub 2005 Oct 31. PMID:16260758

Page seeded by OCA on Mon Jul 28 15:17:24 2008

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