1wz3

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{{STRUCTURE_1wz3| PDB=1wz3 | SCENE= }}
{{STRUCTURE_1wz3| PDB=1wz3 | SCENE= }}
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'''The crystal structure of plant ATG12'''
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===The crystal structure of plant ATG12===
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==Overview==
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Atg12 is a post-translational modifier that is activated and conjugated to its single target, Atg5, by a ubiquitin-like conjugation system. The Atg12-Atg5 conjugate is essential for autophagy, the bulk degradation process of cytoplasmic components by the vacuolar/lysosomal system. Here, we demonstrate that the Atg12 conjugation system exists in Arabidopsis and is essential for plant autophagy as well as in yeast and mammals. We also report the crystal structure of Arabidopsis thaliana (At) ATG12 at 1.8 A resolution. Despite no obvious sequence homology with ubiquitin, the structure of AtATG12 shows a ubiquitin fold strikingly similar to those of mammalian homologs of Atg8, the other ubiquitin-like modifier essential for autophagy, which is conjugated to phosphatidylethanolamine. Two types of hydrophobic patches are present on the surface of AtATG12: one is conserved in both Atg12 and Atg8 orthologs, while the other is unique to Atg12 orthologs. Considering that they share Atg7 as an E1-like enzyme, we suggest that the first hydrophobic patch is responsible for the conjugation reaction, while the latter is involved in Atg12-specific functions.
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The line below this paragraph, {{ABSTRACT_PUBMED_16874047}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 16874047 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16874047}}
==About this Structure==
==About this Structure==
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[[Category: Yoshimoto, K.]]
[[Category: Yoshimoto, K.]]
[[Category: Ubiquitin-fold]]
[[Category: Ubiquitin-fold]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 14:20:12 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 15:23:41 2008''

Revision as of 12:23, 28 July 2008

Image:1wz3.png

Template:STRUCTURE 1wz3

The crystal structure of plant ATG12

Template:ABSTRACT PUBMED 16874047

About this Structure

1WZ3 is a Single protein structure of sequence from Arabidopsis thaliana. Full crystallographic information is available from OCA.

Reference

The crystal structure of plant ATG12 and its biological implication in autophagy., Suzuki NN, Yoshimoto K, Fujioka Y, Ohsumi Y, Inagaki F, Autophagy. 2005 Jul;1(2):119-26. Epub 2005 Jul 23. PMID:16874047

Page seeded by OCA on Mon Jul 28 15:23:41 2008

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