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2f1e

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[[Image:2f1e.gif|left|200px]]
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{{STRUCTURE_2f1e| PDB=2f1e | SCENE= }}
{{STRUCTURE_2f1e| PDB=2f1e | SCENE= }}
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'''Solution structure of ApaG protein'''
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===Solution structure of ApaG protein===
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==Overview==
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ApaG proteins are found in a wide variety of bacterial genomes but their function is as yet unknown. Some eukaryotic proteins involved in protein-protein interactions, such as the human polymerase delta-interacting protein (PDIP38) and the F Box A (FBA) proteins, contain ApaG homology domains. We have used NMR to determine the solution structure of ApaG protein from the plant pathogen Xanthomonas axonopodis pv. citri (ApaG(Xac)) with the aim to shed some light on its molecular function. ApaG(Xac) is characterized by seven antiparallel beta strands forming two beta sheets, one containing three strands (ABE) and the other four strands (GFCC'). Relaxation measurements indicate that the protein has a quite rigid structure. In spite of the presence of a putative GXGXXG pyrophosphate binding motif ApaG(Xac) does not bind ATP or GTP, in vitro. On the other hand, ApaG(Xac) adopts a fibronectin type III (Fn3) fold, which is consistent with the hypothesis that it is involved in mediating protein-protein interactions. The fact that the proteins of ApaG family do not display significant sequence similarity with the Fn3 domains found in other eukaryotic or bacterial proteins suggests that Fn3 domain may have arisen earlier in evolution than previously estimated.
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{{ABSTRACT_PUBMED_17256769}}
==About this Structure==
==About this Structure==
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2F1E is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Xanthomonas_axonopodis_pv._citri Xanthomonas axonopodis pv. citri]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F1E OCA].
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2F1E is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Xanthomonas_axonopodis_pv._citri Xanthomonas axonopodis pv. citri]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F1E OCA].
==Reference==
==Reference==
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[[Category: Nmr]]
[[Category: Nmr]]
[[Category: Xanthomonas axonopodis pv citri]]
[[Category: Xanthomonas axonopodis pv citri]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 03:20:55 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 15:27:52 2008''

Revision as of 12:27, 28 July 2008

Image:2f1e.png

Template:STRUCTURE 2f1e

Solution structure of ApaG protein

Template:ABSTRACT PUBMED 17256769

About this Structure

2F1E is a Single protein structure of sequence from Xanthomonas axonopodis pv. citri. Full experimental information is available from OCA.

Reference

Solution structure of ApaG from Xanthomonas axonopodis pv. citri reveals a fibronectin-3 fold., Cicero DO, Contessa GM, Pertinhez TA, Gallo M, Katsuyama AM, Paci M, Farah CS, Spisni A, Proteins. 2007 May 1;67(2):490-500. PMID:17256769

Page seeded by OCA on Mon Jul 28 15:27:52 2008

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