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1yk8

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[[Image:1yk8.gif|left|200px]]
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{{STRUCTURE_1yk8| PDB=1yk8 | SCENE= }}
{{STRUCTURE_1yk8| PDB=1yk8 | SCENE= }}
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'''Cathepsin K complexed with a cyanamide-based inhibitor'''
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===Cathepsin K complexed with a cyanamide-based inhibitor===
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==Overview==
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Conversion of the proline-derived cyanamide lead to an acyclic cyanamide capable of forming an additional hydrogen bond with cathepsin K resulted in a large increase in inhibitory activity. An X-ray structure of a co-crystal of a cyanamide with cathepsin K confirmed the enzyme interaction. Furthermore, a representative acyclic cyanamide inhibitor 6r was able to attenuate bone resorption in the rat calvarial model.
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(as it appears on PubMed at http://www.pubmed.gov), where 15896958 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15896958}}
==About this Structure==
==About this Structure==
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[[Category: Cysteine]]
[[Category: Cysteine]]
[[Category: Protease]]
[[Category: Protease]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 16:25:30 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 16:05:19 2008''

Revision as of 13:05, 28 July 2008

Image:1yk8.png

Template:STRUCTURE 1yk8

Cathepsin K complexed with a cyanamide-based inhibitor

Template:ABSTRACT PUBMED 15896958

About this Structure

1YK8 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Acyclic cyanamide-based inhibitors of cathepsin K., Barrett DG, Deaton DN, Hassell AM, McFadyen RB, Miller AB, Miller LR, Payne JA, Shewchuk LM, Willard DH Jr, Wright LL, Bioorg Med Chem Lett. 2005 Jun 15;15(12):3039-43. PMID:15896958

Page seeded by OCA on Mon Jul 28 16:05:19 2008

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