1w3s

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{{STRUCTURE_1w3s| PDB=1w3s | SCENE= }}
{{STRUCTURE_1w3s| PDB=1w3s | SCENE= }}
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'''THE CRYSTAL STRUCTURE OF RECO FROM DEINOCOCCUS RADIODURANS.'''
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===THE CRYSTAL STRUCTURE OF RECO FROM DEINOCOCCUS RADIODURANS.===
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==Overview==
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The RecFOR pathway has been shown to be essential for DNA repair through the process of homologous recombination in bacteria and, recently, to be important in the recovery of stalled replication forks following UV irradiation. RecO, along with RecR, RecF, RecQ and RecJ, is a principal actor in this fundamental DNA repair pathway. Here we present the three-dimensional structure of a member of the RecO family. The crystal structure of Deinococcus radiodurans RecO (drRecO) reveals possible binding sites for DNA and for the RecO-binding proteins within its three discrete structural regions: an N-terminal oligonucleotide/oligosaccharide-binding domain, a helical bundle and a zinc-finger motif. Furthermore, drRecO was found to form a stable complex with RecR and to bind both single- and double-stranded DNA. Mutational analysis confirmed the existence of multiple DNA-binding sites within the protein.
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(as it appears on PubMed at http://www.pubmed.gov), where 15719017 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15719017}}
==About this Structure==
==About this Structure==
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[[Category: Reco]]
[[Category: Reco]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 13:07:10 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 16:27:18 2008''

Revision as of 13:27, 28 July 2008

Image:1w3s.png

Template:STRUCTURE 1w3s

THE CRYSTAL STRUCTURE OF RECO FROM DEINOCOCCUS RADIODURANS.

Template:ABSTRACT PUBMED 15719017

About this Structure

1W3S is a Single protein structure of sequence from Deinococcus radiodurans. Full crystallographic information is available from OCA.

Reference

Crystal structure and DNA-binding analysis of RecO from Deinococcus radiodurans., Leiros I, Timmins J, Hall DR, McSweeney S, EMBO J. 2005 Mar 9;24(5):906-18. Epub 2005 Feb 17. PMID:15719017

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