2as0

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{{STRUCTURE_2as0| PDB=2as0 | SCENE= }}
{{STRUCTURE_2as0| PDB=2as0 | SCENE= }}
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'''Crystal Structure of PH1915 (APC 5817): A Hypothetical RNA Methyltransferase'''
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===Crystal Structure of PH1915 (APC 5817): A Hypothetical RNA Methyltransferase===
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==Overview==
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The S-adenosyl-L-methionine (SAM)-dependent methyltransferases represent a diverse and biologically important class of enzymes. These enzymes utilize the ubiquitous methyl donor SAM as a cofactor to methylate proteins, small molecules, lipids, and nucleic acids. Here we present the crystal structure of PH1915 from Pyrococcus horikoshii OT3, a predicted SAM-dependent methyltransferase. This protein belongs to the Cluster of Orthologous Group 1092, and the presented crystal structure is the first representative structure of this protein family. Based on sequence and 3D structure analysis, we have made valuable functional insights that will facilitate further studies for characterizing this group of proteins. Specifically, we propose that PH1915 and its orthologs are rRNA- or tRNA-specific methyltransferases.
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{{ABSTRACT_PUBMED_16260766}}
==About this Structure==
==About this Structure==
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[[Category: Rna methyltransferase]]
[[Category: Rna methyltransferase]]
[[Category: Structural genomic]]
[[Category: Structural genomic]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 16:33:46 2008''

Revision as of 13:33, 28 July 2008

Image:2as0.png

Template:STRUCTURE 2as0

Crystal Structure of PH1915 (APC 5817): A Hypothetical RNA Methyltransferase

Template:ABSTRACT PUBMED 16260766

About this Structure

2AS0 is a Single protein structure of sequence from Pyrococcus horikoshii. Full crystallographic information is available from OCA.

Reference

The crystal structure of a novel SAM-dependent methyltransferase PH1915 from Pyrococcus horikoshii., Sun W, Xu X, Pavlova M, Edwards AM, Joachimiak A, Savchenko A, Christendat D, Protein Sci. 2005 Dec;14(12):3121-8. Epub 2005 Oct 31. PMID:16260766

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