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1zih

From Proteopedia

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[[Image:1zih.gif|left|200px]]
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{{STRUCTURE_1zih| PDB=1zih | SCENE= }}
{{STRUCTURE_1zih| PDB=1zih | SCENE= }}
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'''GCAA RNA TETRALOOP, NMR, 10 STRUCTURES'''
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===GCAA RNA TETRALOOP, NMR, 10 STRUCTURES===
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==Overview==
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RNA hairpin loops containing a GNRA consensus sequence are the most frequently occurring hairpins in a variety of prokaryotic and eukaryotic RNAs. These tetraloops play important functional roles in RNA folding, in RNA-RNA tertiary interactions and as protein binding sites. Homo and heteronuclear NMR spectroscopy have been used to determine the structures of the most abundant members of the GNRA tetraloop family: the GAGA, GCAA and GAAA loops closed by a C-G base pair. Analysis of the structures of these three hairpin loops reveals a network of heterogeneous hydrogen bonds. The loops contain a G-A base pair, a G base-phosphate hydrogen bond and several 2' OH-base hydrogen bonds. These intramolecular interactions and the extensive base stacking in the loop help explain the high thermodynamic stability and give insight into the diverse biological roles of the GNRA RNA hairpins.
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The line below this paragraph, {{ABSTRACT_PUBMED_9000624}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 9000624 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9000624}}
==About this Structure==
==About this Structure==
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZIH OCA].
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Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZIH OCA].
==Reference==
==Reference==
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[[Category: Rna]]
[[Category: Rna]]
[[Category: Tetraloop]]
[[Category: Tetraloop]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 17:40:00 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 16:34:52 2008''

Revision as of 13:34, 28 July 2008

Image:1zih.png

Template:STRUCTURE 1zih

GCAA RNA TETRALOOP, NMR, 10 STRUCTURES

Template:ABSTRACT PUBMED 9000624

About this Structure

Full experimental information is available from OCA.

Reference

A network of heterogeneous hydrogen bonds in GNRA tetraloops., Jucker FM, Heus HA, Yip PF, Moors EH, Pardi A, J Mol Biol. 1996 Dec 20;264(5):968-80. PMID:9000624

Page seeded by OCA on Mon Jul 28 16:34:52 2008

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