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1n9p

From Proteopedia

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[[Image:1n9p.png|left|200px]]
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{{STRUCTURE_1n9p| PDB=1n9p | SCENE= }}
{{STRUCTURE_1n9p| PDB=1n9p | SCENE= }}
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'''Crystal Structure of the Cytoplasmic Domain of G-protein Activated Inward Rectifier Potassium Channel 1'''
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===Crystal Structure of the Cytoplasmic Domain of G-protein Activated Inward Rectifier Potassium Channel 1===
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==Overview==
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<!--
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Inward rectifier K(+) channels govern the resting membrane voltage in many cells. Regulation of these ion channels via G protein-coupled receptor signaling underlies the control of heart rate and the actions of neurotransmitters in the central nervous system. We have determined the protein structure formed by the intracellular N- and C termini of the G protein-gated inward rectifier K(+) channel GIRK1 at 1.8 A resolution. A cytoplasmic pore, conserved among inward rectifier K(+) channels, extends the ion pathway to 60 A, nearly twice the length of a canonical transmembrane K(+) channel. The cytoplasmic pore is lined by acidic and hydrophobic amino acids, creating a favorable environment for polyamines, which block the pore. These results explain in structural and chemical terms the basis of inward rectification, and they also have implications for G protein regulation of GIRK channels.
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The line below this paragraph, {{ABSTRACT_PUBMED_12507423}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 12507423 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12507423}}
==About this Structure==
==About this Structure==
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[[Category: Potassium channel]]
[[Category: Potassium channel]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun 25 04:51:45 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 16:36:05 2008''

Revision as of 13:36, 28 July 2008

Image:1n9p.png

Template:STRUCTURE 1n9p

Crystal Structure of the Cytoplasmic Domain of G-protein Activated Inward Rectifier Potassium Channel 1

Template:ABSTRACT PUBMED 12507423

About this Structure

1N9P is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

Structural basis of inward rectification: cytoplasmic pore of the G protein-gated inward rectifier GIRK1 at 1.8 A resolution., Nishida M, MacKinnon R, Cell. 2002 Dec 27;111(7):957-65. PMID:12507423

Page seeded by OCA on Mon Jul 28 16:36:05 2008

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