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1t1v

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{{STRUCTURE_1t1v| PDB=1t1v | SCENE= }}
{{STRUCTURE_1t1v| PDB=1t1v | SCENE= }}
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'''Crystal Structure of the Glutaredoxin-like Protein SH3BGRL3 at 1.6 A resolution'''
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===Crystal Structure of the Glutaredoxin-like Protein SH3BGRL3 at 1.6 A resolution===
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==Overview==
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We report the 1.6 Angstrom resolution crystal structure of SH3BGRL3, a member of a new mammalian protein family of unknown function. The observed "thioredoxin fold" of SH3BGRL3 matches the tertiary structure of glutaredoxins, even in the N-terminal region where the sequence similarity between the two protein families is negligible. In particular, SH3BGRL3 displays structural modifications at the N-terminal Cys-x-x-Cys loop, responsible for glutathione binding and catalysis in glutaredoxins. The loop hosts a six residue insertion, yielding an extra N-terminal-capped helical turn, first observed here for the thioredoxin fold. This, together with deletion of both Cys residues, results in a substantial reshaping of the neighboring cleft, where glutathione is hosted in glutaredoxins. While not active in redox reaction and glutathione binding, SH3BGRL3 may act as an endogenous modulator of glutaredoxin activities by competing, with its fully conserved thioredoxin fold, for binding to yet unknown target proteins.
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{{ABSTRACT_PUBMED_15120624}}
==About this Structure==
==About this Structure==
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[[Category: Thioredoxin fold]]
[[Category: Thioredoxin fold]]
[[Category: X-ray crystallography]]
[[Category: X-ray crystallography]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 09:24:17 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 16:44:32 2008''

Revision as of 13:44, 28 July 2008

Image:1t1v.png

Template:STRUCTURE 1t1v

Crystal Structure of the Glutaredoxin-like Protein SH3BGRL3 at 1.6 A resolution

Template:ABSTRACT PUBMED 15120624

About this Structure

1T1V is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

Crystal structure of the glutaredoxin-like protein SH3BGRL3 at 1.6 Angstrom resolution., Nardini M, Mazzocco M, Massaro A, Maffei M, Vergano A, Donadini A, Scartezzini P, Bolognesi M, Biochem Biophys Res Commun. 2004 May 28;318(2):470-6. PMID:15120624

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