3c4z

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:3c4z.jpg|left|200px]]
+
{{Seed}}
 +
[[Image:3c4z.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_3c4z| PDB=3c4z | SCENE= }}
{{STRUCTURE_3c4z| PDB=3c4z | SCENE= }}
-
'''Crystal structure of G protein coupled receptor kinase 1 bound to ADP and magnesium chloride at 1.84A'''
+
===Crystal structure of G protein coupled receptor kinase 1 bound to ADP and magnesium chloride at 1.84A===
-
==Overview==
+
<!--
-
G protein-coupled receptor (GPCR) kinases (GRKs) phosphorylate activated heptahelical receptors, leading to their uncoupling from G proteins. Here we report six crystal structures of rhodopsin kinase (GRK1), revealing not only three distinct nucleotide-binding states of a GRK but also two key structural elements believed to be involved in the recognition of activated GPCRs. The first is the C-terminal extension of the kinase domain, which was observed in all nucleotide-bound GRK1 structures. The second is residues 5-30 of the N terminus, observed in one of the GRK1.(Mg(2+))(2).ATP structures. The N terminus was also clearly phosphorylated, leading to the identification of two novel phosphorylation sites by mass spectral analysis. Co-localization of the N terminus and the C-terminal extension near the hinge of the kinase domain suggests that activated GPCRs stimulate kinase activity by binding to this region to facilitate full closure of the kinase domain.
+
The line below this paragraph, {{ABSTRACT_PUBMED_18339619}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 18339619 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_18339619}}
==About this Structure==
==About this Structure==
Line 43: Line 47:
[[Category: Serine/threonine-protein kinase]]
[[Category: Serine/threonine-protein kinase]]
[[Category: Transferase]]
[[Category: Transferase]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu May 22 22:36:48 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 16:46:09 2008''

Revision as of 13:46, 28 July 2008

Image:3c4z.png

Template:STRUCTURE 3c4z

Crystal structure of G protein coupled receptor kinase 1 bound to ADP and magnesium chloride at 1.84A

Template:ABSTRACT PUBMED 18339619

About this Structure

3C4Z is a Single protein structure of sequence from Bos taurus. Full crystallographic information is available from OCA.

Reference

Structures of Rhodopsin Kinase in Different Ligand States Reveal Key Elements Involved in G Protein-coupled Receptor Kinase Activation., Singh P, Wang B, Maeda T, Palczewski K, Tesmer JJ, J Biol Chem. 2008 May 16;283(20):14053-62. Epub 2008 Mar 13. PMID:18339619

Page seeded by OCA on Mon Jul 28 16:46:09 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3c4z"
Personal tools