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2gk2

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{{STRUCTURE_2gk2| PDB=2gk2 | SCENE= }}
{{STRUCTURE_2gk2| PDB=2gk2 | SCENE= }}
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'''Crystal structure of the N terminal domain of human CEACAM1'''
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===Crystal structure of the N terminal domain of human CEACAM1===
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==Overview==
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CEACAM1 is a cellular adhesion molecule whose protein expression is down-regulated in several carcinomas and which also contributes to the pathogenicity of Neisseria by acting as a receptor for Opa proteins. The crystal structure of the N-terminal (D1) domain of human CEACAM1 has been determined at 2.2 Angstrom resolution. The structure shows several differences compared with a lower resolution model of the same domain from mouse solved previously, especially in the functional regions. Mapping of the sites of mutations that lower or abolish the binding of CEACAM1 to Opa proteins shows a distinct clustering of residues on the GFCC'C'' face of the molecule. Prominent amongst these are residues in the C, C' and F strands and the CC' loop. A similar analysis shows that the region responsible for homophilic or heterophilic interactions of CEACAM1 is also on the GFCC'C'' face and overlaps partially with the Opa-binding region. This higher resolution structure of CEACAM1 will facilitate a more precise dissection of its functional regions in the context of neisserial pathogenesis, cellular adhesion and immune evasion.
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(as it appears on PubMed at http://www.pubmed.gov), where 16929097 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16929097}}
==About this Structure==
==About this Structure==
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[[Category: Adhesion protein]]
[[Category: Adhesion protein]]
[[Category: Immunoglobulin domain]]
[[Category: Immunoglobulin domain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 05:11:52 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 16:51:14 2008''

Revision as of 13:51, 28 July 2008

Image:2gk2.png

Template:STRUCTURE 2gk2

Crystal structure of the N terminal domain of human CEACAM1

Template:ABSTRACT PUBMED 16929097

About this Structure

2GK2 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure of the N-terminal domain of human CEACAM1: binding target of the opacity proteins during invasion of Neisseria meningitidis and N. gonorrhoeae., Fedarovich A, Tomberg J, Nicholas RA, Davies C, Acta Crystallogr D Biol Crystallogr. 2006 Sep;62(Pt 9):971-9. Epub 2006, Aug 19. PMID:16929097

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