2oyp

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:2oyp.gif|left|200px]]
+
{{Seed}}
 +
[[Image:2oyp.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_2oyp| PDB=2oyp | SCENE= }}
{{STRUCTURE_2oyp| PDB=2oyp | SCENE= }}
-
'''T Cell Immunoglobulin Mucin-3 Crystal Structure Revealed a Galectin-9-independent Binding Surface'''
+
===T Cell Immunoglobulin Mucin-3 Crystal Structure Revealed a Galectin-9-independent Binding Surface===
-
==Overview==
+
<!--
-
The T cell immunoglobulin mucin (Tim) family of receptors regulates effector CD4(+) T cell functions and is implicated in autoimmune and allergic diseases. Tim-3 induces immunological tolerance, and engagement of the Tim-3 immunoglobulin variable (IgV) domain by galectin-9 is important for appropriate termination of T helper 1-immune responses. The 2 A crystal structure of the Tim-3 IgV domain demonstrated that four cysteines, which are invariant within the Tim family, form two noncanonical disulfide bonds, resulting in a surface not present in other immunoglobulin superfamily members. Biochemical and biophysical studies demonstrated that this unique structural feature mediates a previously unidentified galectin-9-independent binding process and suggested that this structural feature is conserved within the entire Tim family. The current work provided a graphic example of the relationship between sequence, structure, and function and suggested that the interplay between multiple Tim-3-binding activities contributes to the regulated assembly of signaling complexes required for effective Th1-mediated immunity.
+
The line below this paragraph, {{ABSTRACT_PUBMED_17363302}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 17363302 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_17363302}}
==About this Structure==
==About this Structure==
Line 30: Line 34:
[[Category: T-cell immunoglobulin mucin]]
[[Category: T-cell immunoglobulin mucin]]
[[Category: Tim-3]]
[[Category: Tim-3]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 11:56:40 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 16:54:11 2008''

Revision as of 13:54, 28 July 2008

Image:2oyp.png

Template:STRUCTURE 2oyp

T Cell Immunoglobulin Mucin-3 Crystal Structure Revealed a Galectin-9-independent Binding Surface

Template:ABSTRACT PUBMED 17363302

About this Structure

2OYP is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

T cell immunoglobulin mucin-3 crystal structure reveals a galectin-9-independent ligand-binding surface., Cao E, Zang X, Ramagopal UA, Mukhopadhaya A, Fedorov A, Fedorov E, Zencheck WD, Lary JW, Cole JL, Deng H, Xiao H, Dilorenzo TP, Allison JP, Nathenson SG, Almo SC, Immunity. 2007 Mar;26(3):311-21. PMID:17363302

Page seeded by OCA on Mon Jul 28 16:54:11 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2oyp"
Personal tools