2com

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[[Image:2com.gif|left|200px]]
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{{Seed}}
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[[Image:2com.png|left|200px]]
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{{STRUCTURE_2com| PDB=2com | SCENE= }}
{{STRUCTURE_2com| PDB=2com | SCENE= }}
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'''The solution structure of the SWIRM domain of human LSD1'''
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===The solution structure of the SWIRM domain of human LSD1===
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==Overview==
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SWIRM is an evolutionarily conserved domain involved in several chromatin-modifying complexes. Recently, the LSD1 protein, which bears a SWIRM domain, was found to be a demethylase for Lys4-methylated histone H3. Here, we report a solution structure of the SWIRM domain of human LSD1. It forms a compact fold composed of 6 alpha helices, in which a 20 amino acid long helix (alpha4) is surrounded by 5 other short helices. The SWIRM domain structure could be divided into the N-terminal part (alpha1-alpha3) and the C-terminal part (alpha4-alpha6), which are connected to each other by a salt bridge. While the N-terminal part forms a SWIRM-specific structure, the C-terminal part adopts a helix-turn-helix (HTH)-related fold. We discuss a model in which the SWIRM domain acts as an anchor site for a histone tail.
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The line below this paragraph, {{ABSTRACT_PUBMED_16531230}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 16531230 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16531230}}
==About this Structure==
==About this Structure==
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2COM is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2COM OCA].
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2COM is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2COM OCA].
==Reference==
==Reference==
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[[Category: Structural genomic]]
[[Category: Structural genomic]]
[[Category: Swirm domain]]
[[Category: Swirm domain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 22:40:38 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 17:01:55 2008''

Revision as of 14:01, 28 July 2008

Image:2com.png

Template:STRUCTURE 2com

The solution structure of the SWIRM domain of human LSD1

Template:ABSTRACT PUBMED 16531230

About this Structure

2COM is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

Solution structure of the SWIRM domain of human histone demethylase LSD1., Tochio N, Umehara T, Koshiba S, Inoue M, Yabuki T, Aoki M, Seki E, Watanabe S, Tomo Y, Hanada M, Ikari M, Sato M, Terada T, Nagase T, Ohara O, Shirouzu M, Tanaka A, Kigawa T, Yokoyama S, Structure. 2006 Mar;14(3):457-68. PMID:16531230

Page seeded by OCA on Mon Jul 28 17:01:55 2008

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