1sox

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{{STRUCTURE_1sox| PDB=1sox | SCENE= }}
{{STRUCTURE_1sox| PDB=1sox | SCENE= }}
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'''SULFITE OXIDASE FROM CHICKEN LIVER'''
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===SULFITE OXIDASE FROM CHICKEN LIVER===
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==Overview==
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The molybdenum-containing enzyme sulfite oxidase catalyzes the conversion of sulfite to sulfate, the terminal step in the oxidative degradation of cysteine and methionine. Deficiency of this enzyme in humans usually leads to major neurological abnormalities and early death. The crystal structure of chicken liver sulfite oxidase at 1.9 A resolution reveals that each monomer of the dimeric enzyme consists of three domains. At the active site, the Mo is penta-coordinated by three sulfur ligands, one oxo group, and one water/hydroxo. A sulfate molecule adjacent to the Mo identifies the substrate binding pocket. Four variants associated with sulfite oxidase deficiency have been identified: two mutations are near the sulfate binding site, while the other mutations occur within the domain mediating dimerization.
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(as it appears on PubMed at http://www.pubmed.gov), where 9428520 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9428520}}
==About this Structure==
==About this Structure==
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[[Category: Oxidoreductase]]
[[Category: Oxidoreductase]]
[[Category: Sulfite oxidation]]
[[Category: Sulfite oxidation]]
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Revision as of 14:07, 28 July 2008

Image:1sox.png

Template:STRUCTURE 1sox

SULFITE OXIDASE FROM CHICKEN LIVER

Template:ABSTRACT PUBMED 9428520

About this Structure

1SOX is a Single protein structure of sequence from Gallus gallus. Full crystallographic information is available from OCA.

Reference

Molecular basis of sulfite oxidase deficiency from the structure of sulfite oxidase., Kisker C, Schindelin H, Pacheco A, Wehbi WA, Garrett RM, Rajagopalan KV, Enemark JH, Rees DC, Cell. 1997 Dec 26;91(7):973-83. PMID:9428520

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