1ww4

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{{STRUCTURE_1ww4| PDB=1ww4 | SCENE= }}
{{STRUCTURE_1ww4| PDB=1ww4 | SCENE= }}
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'''Agrocybe cylindracea galectin complexed with NeuAca2-3lactose'''
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===Agrocybe cylindracea galectin complexed with NeuAca2-3lactose===
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==Overview==
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Galectin from an edible fungus Agrocybe cylindracea (ACG) has a strong preference for N-acetylneuraminyl lactose (NeuAcalpha2-3lactose). The sugar recognition mechanism of ACG was explored by the X-ray crystallographic analyses of ligand-free ACG, and its complex with lactose, 3'-sulfonyl lactose and NeuAcalpha2-3lactose. The refined structure shows that ACG is a "proto"-type galectin composed of a beta-sandwich of two antiparallel sheets, each with six strands, in contrast to the five and six strands in animal galectins. ACG dimer in solution was classified as being among the "layer"-type. The carbohydrate recognition domain (CRD) of this galectin is common to those of animal galectins, except for substitution of one residue, Ala64, which corresponds to Asn46 in human galectin 1. A five-residue insertion in ACG at positions 42-46 involving Ser44 and Asn46 modified the architecture of the sugar binding site that contributes sialic acid specificity. Furthermore, it was found that the binding of a sulfate ion near the CRD in the ligand-free form led to a change in the conformation of the loop region caused by main-chain cis/trans transition between Ser44 and Pro45.
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(as it appears on PubMed at http://www.pubmed.gov), where 16051274 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16051274}}
==About this Structure==
==About this Structure==
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[[Category: N-acetylneuraminyl lactose]]
[[Category: N-acetylneuraminyl lactose]]
[[Category: X-ray crystallographic analysis]]
[[Category: X-ray crystallographic analysis]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 17:48:29 2008''

Revision as of 14:48, 28 July 2008

Image:1ww4.png

Template:STRUCTURE 1ww4

Agrocybe cylindracea galectin complexed with NeuAca2-3lactose

Template:ABSTRACT PUBMED 16051274

About this Structure

Full crystallographic information is available from OCA.

Reference

Structural basis of a fungal galectin from Agrocybe cylindracea for recognizing sialoconjugate., Ban M, Yoon HJ, Demirkan E, Utsumi S, Mikami B, Yagi F, J Mol Biol. 2005 Aug 26;351(4):695-706. PMID:16051274

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