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1z50

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[[Image:1z50.gif|left|200px]]
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{{STRUCTURE_1z50| PDB=1z50 | SCENE= }}
{{STRUCTURE_1z50| PDB=1z50 | SCENE= }}
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'''Parainfluenza Virus 5 (SV5) Hemagglutinin-Neuraminidase (HN) with ligand DANA (soaked with sialic acid, pH 8.0)'''
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===Parainfluenza Virus 5 (SV5) Hemagglutinin-Neuraminidase (HN) with ligand DANA (soaked with sialic acid, pH 8.0)===
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==Overview==
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The paramyxovirus hemagglutinin-neuraminidase (HN) functions in virus attachment to cells, cleavage of sialic acid from oligosaccharides, and stimulating membrane fusion during virus entry into cells. The structural basis for these diverse functions remains to be fully understood. We report the crystal structures of the parainfluenza virus 5 (SV5) HN and its complexes with sialic acid, the inhibitor DANA, and the receptor sialyllactose. SV5 HN shares common structural features with HN of Newcastle disease virus (NDV) and human parainfluenza 3 (HPIV3), but unlike the previously determined HN structures, the SV5 HN forms a tetramer in solution, which is thought to be the physiological oligomer. The sialyllactose complex reveals intact receptor within the active site, but no major conformational changes in the protein. The SV5 HN structures do not support previously proposed models for HN action in membrane fusion and suggest alternative mechanisms by which HN may promote virus entry into cells.
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The line below this paragraph, {{ABSTRACT_PUBMED_15893670}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 15893670 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15893670}}
==About this Structure==
==About this Structure==
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[[Category: Yuan, P.]]
[[Category: Yuan, P.]]
[[Category: Hemagglutinin,neuraminidase,fusion,tetramer]]
[[Category: Hemagglutinin,neuraminidase,fusion,tetramer]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 17:11:05 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 18:00:24 2008''

Revision as of 15:00, 28 July 2008

Image:1z50.gif

Template:STRUCTURE 1z50

Parainfluenza Virus 5 (SV5) Hemagglutinin-Neuraminidase (HN) with ligand DANA (soaked with sialic acid, pH 8.0)

Template:ABSTRACT PUBMED 15893670

About this Structure

1Z50 is a Single protein structure of sequence from Simian virus 5. Full crystallographic information is available from OCA.

Reference

Structural studies of the parainfluenza virus 5 hemagglutinin-neuraminidase tetramer in complex with its receptor, sialyllactose., Yuan P, Thompson TB, Wurzburg BA, Paterson RG, Lamb RA, Jardetzky TS, Structure. 2005 May;13(5):803-15. PMID:15893670

Page seeded by OCA on Mon Jul 28 18:00:24 2008

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