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2a5f

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[[Image:2a5f.gif|left|200px]]
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{{Seed}}
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{{STRUCTURE_2a5f| PDB=2a5f | SCENE= }}
{{STRUCTURE_2a5f| PDB=2a5f | SCENE= }}
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'''Cholera toxin A1 subunit bound to its substrate, NAD+, and its human protein activator, ARF6'''
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===Cholera toxin A1 subunit bound to its substrate, NAD+, and its human protein activator, ARF6===
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==Overview==
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The Vibrio cholerae bacterium causes devastating diarrhea when it infects the human intestine. The key event is adenosine diphosphate (ADP)-ribosylation of the human signaling protein GSalpha, catalyzed by the cholera toxin A1 subunit (CTA1). This reaction is allosterically activated by human ADP-ribosylation factors (ARFs), a family of essential and ubiquitous G proteins. Crystal structures of a CTA1:ARF6-GTP (guanosine triphosphate) complex reveal that binding of the human activator elicits dramatic changes in CTA1 loop regions that allow nicotinamide adenine dinucleotide (NAD+) to bind to the active site. The extensive toxin:ARF-GTP interface surface mimics ARF-GTP recognition of normal cellular protein partners, which suggests that the toxin has evolved to exploit promiscuous binding properties of ARFs.
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(as it appears on PubMed at http://www.pubmed.gov), where 16099990 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16099990}}
==About this Structure==
==About this Structure==
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[[Category: Neal, C J.O.]]
[[Category: Neal, C J.O.]]
[[Category: Protein transport/transferase]]
[[Category: Protein transport/transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 18:37:47 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 18:26:56 2008''

Revision as of 15:26, 28 July 2008

Image:2a5f.jpg

Template:STRUCTURE 2a5f

Cholera toxin A1 subunit bound to its substrate, NAD+, and its human protein activator, ARF6

Template:ABSTRACT PUBMED 16099990

About this Structure

2A5F is a Protein complex structure of sequences from Homo sapiens and Vibrio cholerae. Full crystallographic information is available from OCA.

Reference

Structural basis for the activation of cholera toxin by human ARF6-GTP., O'Neal CJ, Jobling MG, Holmes RK, Hol WG, Science. 2005 Aug 12;309(5737):1093-6. PMID:16099990

Page seeded by OCA on Mon Jul 28 18:26:56 2008

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