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2a4h

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{{STRUCTURE_2a4h| PDB=2a4h | SCENE= }}
{{STRUCTURE_2a4h| PDB=2a4h | SCENE= }}
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'''Solution structure of Sep15 from Drosophila melanogaster'''
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===Solution structure of Sep15 from Drosophila melanogaster===
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==Overview==
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Selenium has significant health benefits, including potent cancer prevention activity and roles in immune function and the male reproductive system. Selenium-containing proteins, which incorporate this essential micronutrient as selenocysteine, are proposed to mediate the positive effects of dietary selenium. Presented here are the solution NMR structures of the selenoprotein SelM and an ortholog of the selenoprotein Sep15. These data reveal that Sep15 and SelM are structural homologs that establish a new thioredoxin-like protein family. The location of the active-site redox motifs within the fold together with the observed localized conformational changes after thiol-disulfide exchange and measured redox potential indicate that they have redox activity. In mammals, Sep15 expression is regulated by dietary selenium, and either decreased or increased expression of this selenoprotein alters redox homeostasis. A physiological role for Sep15 and SelM as thiol-disulfide oxidoreductases and their contribution to the quality control pathways of the endoplasmic reticulum are discussed.
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The line below this paragraph, {{ABSTRACT_PUBMED_16319061}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 16319061 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16319061}}
==About this Structure==
==About this Structure==
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2A4H is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A4H OCA].
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2A4H is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A4H OCA].
==Reference==
==Reference==
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[[Category: Redox]]
[[Category: Redox]]
[[Category: Selenoprotein]]
[[Category: Selenoprotein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 18:35:27 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 18:44:35 2008''

Revision as of 15:44, 28 July 2008

Image:2a4h.gif

Template:STRUCTURE 2a4h

Solution structure of Sep15 from Drosophila melanogaster

Template:ABSTRACT PUBMED 16319061

About this Structure

2A4H is a Single protein structure of sequence from Drosophila melanogaster. Full experimental information is available from OCA.

Reference

NMR structures of the selenoproteins Sep15 and SelM reveal redox activity of a new thioredoxin-like family., Ferguson AD, Labunskyy VM, Fomenko DE, Arac D, Chelliah Y, Amezcua CA, Rizo J, Gladyshev VN, Deisenhofer J, J Biol Chem. 2006 Feb 10;281(6):3536-43. Epub 2005 Nov 30. PMID:16319061

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