2ao6

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{{STRUCTURE_2ao6| PDB=2ao6 | SCENE= }}
{{STRUCTURE_2ao6| PDB=2ao6 | SCENE= }}
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'''Crystal structure of the human androgen receptor ligand binding domain bound with TIF2(iii) 740-753 peptide and R1881'''
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===Crystal structure of the human androgen receptor ligand binding domain bound with TIF2(iii) 740-753 peptide and R1881===
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==Overview==
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The androgen receptor (AR) is required for male sex development and contributes to prostate cancer cell survival. In contrast to other nuclear receptors that bind the LXXLL motifs of coactivators, the AR ligand binding domain is preferentially engaged in an interdomain interaction with the AR FXXLF motif. Reported here are crystal structures of the ligand-activated AR ligand binding domain with and without bound FXXLF and LXXLL peptides. Key residues that establish motif binding specificity are identified through comparative structure-function and mutagenesis studies. A mechanism in prostate cancer is suggested by a functional AR mutation at a specificity-determining residue that recovers coactivator LXXLL motif binding. An activation function transition hypothesis is proposed in which an evolutionary decline in LXXLL motif binding parallels expansion and functional dominance of the NH(2)-terminal transactivation domain in the steroid receptor subfamily.
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(as it appears on PubMed at http://www.pubmed.gov), where 15525515 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15525515}}
==About this Structure==
==About this Structure==
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[[Category: R188]]
[[Category: R188]]
[[Category: Transcriptional intermediary factor 2 740-753]]
[[Category: Transcriptional intermediary factor 2 740-753]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 19:16:43 2008''
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Revision as of 15:45, 28 July 2008

Image:2ao6.png

Template:STRUCTURE 2ao6

Crystal structure of the human androgen receptor ligand binding domain bound with TIF2(iii) 740-753 peptide and R1881

Template:ABSTRACT PUBMED 15525515

About this Structure

2AO6 is a Protein complex structure of sequences from Homo sapiens. This structure supersedes the now removed PDB entry 1xq2. Full crystallographic information is available from OCA.

Reference

Structural basis for androgen receptor interdomain and coactivator interactions suggests a transition in nuclear receptor activation function dominance., He B, Gampe RT Jr, Kole AJ, Hnat AT, Stanley TB, An G, Stewart EL, Kalman RI, Minges JT, Wilson EM, Mol Cell. 2004 Nov 5;16(3):425-38. PMID:15525515

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