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272d

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{{STRUCTURE_272d| PDB=272d | SCENE= }}
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'''PARALLEL AND ANTIPARALLEL (G.GC)2 TRIPLE HELIX FRAGMENTS IN A CRYSTAL STRUCTURE'''
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===PARALLEL AND ANTIPARALLEL (G.GC)2 TRIPLE HELIX FRAGMENTS IN A CRYSTAL STRUCTURE===
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==Overview==
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Nucleic acid triplexes are formed by sequence-specific interactions between single-stranded polynucleotides and the double helix. These triplexes are implicated in genetic recombination in vivo and have application to areas that include genome analysis and antigene therapy. Despite the importance of the triple helix, only limited high-resolution structural information is available. The x-ray crystal structure of the oligonucleotide d(GGCCAATTGG) is described; it was designed to contain the d(G middle dotGC)2 fragment and thus provide the basic repeat unit of a DNA triple helix. Parameters derived from this crystal structure have made it possible to construct models of both parallel and antiparallel triple helices.
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(as it appears on PubMed at http://www.pubmed.gov), where 8781231 is the PubMed ID number.
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{{ABSTRACT_PUBMED_8781231}}
==About this Structure==
==About this Structure==
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[[Category: Intermolecular base triplet]]
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[[Category: Overhanging base]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 18:51:19 2008''

Revision as of 15:51, 28 July 2008

Image:272d.png

Template:STRUCTURE 272d

PARALLEL AND ANTIPARALLEL (G.GC)2 TRIPLE HELIX FRAGMENTS IN A CRYSTAL STRUCTURE

Template:ABSTRACT PUBMED 8781231

About this Structure

Full crystallographic information is available from OCA.

Reference

Parallel and antiparallel (G.GC)2 triple helix fragments in a crystal structure., Vlieghe D, Van Meervelt L, Dautant A, Gallois B, Precigoux G, Kennard O, Science. 1996 Sep 20;273(5282):1702-5. PMID:8781231

Page seeded by OCA on Mon Jul 28 18:51:19 2008

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