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1q6x

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[[Image:1q6x.gif|left|200px]]
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{{Seed}}
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[[Image:1q6x.png|left|200px]]
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{{STRUCTURE_1q6x| PDB=1q6x | SCENE= }}
{{STRUCTURE_1q6x| PDB=1q6x | SCENE= }}
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'''Crystal structure of rat choline acetyltransferase'''
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===Crystal structure of rat choline acetyltransferase===
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==Overview==
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Choline acetyltransferase (ChAT) synthesizes acetylcholine in neurons and other cell types. Decreases in ChAT activity are associated with a number of disease states, and mutations in ChAT cause congenital neuromuscular disorders. The crystal structure of ChAT reported here shows the enzyme divided into two domains with the active site in a solvent accessible tunnel at the domain interface. A low-resolution view of the complex with one substrate, coenzyme A, defines its binding site and suggests an additional interaction not found in the related carnitine acetyltransferase. Also, the preference for choline over carnitine as an acetyl acceptor is seen to result from both electrostatic and steric blocks to carnitine binding at the active site. While half of the mutations that cause motor disorders are positioned to affect enzyme activity directly, the remaining changes are surprisingly distant from the active site and must exert indirect effects. The structure indicates how ChAT is regulated by phosphorylation and reveals an unusual pattern of basic surface patches that may mediate membrane association or macromolecular interactions.
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(as it appears on PubMed at http://www.pubmed.gov), where 15131697 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15131697}}
==About this Structure==
==About this Structure==
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 05:56:41 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 19:06:39 2008''

Revision as of 16:06, 28 July 2008

Image:1q6x.png

Template:STRUCTURE 1q6x

Crystal structure of rat choline acetyltransferase

Template:ABSTRACT PUBMED 15131697

About this Structure

1Q6X is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

Choline acetyltransferase structure reveals distribution of mutations that cause motor disorders., Cai Y, Cronin CN, Engel AG, Ohno K, Hersh LB, Rodgers DW, EMBO J. 2004 May 19;23(10):2047-58. Epub 2004 May 6. PMID:15131697

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