1v3e

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{{STRUCTURE_1v3e| PDB=1v3e | SCENE= }}
{{STRUCTURE_1v3e| PDB=1v3e | SCENE= }}
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'''Structure of the hemagglutinin-neuraminidase from human parainfluenza virus type III: complex with ZANAMAVIR'''
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===Structure of the hemagglutinin-neuraminidase from human parainfluenza virus type III: complex with ZANAMAVIR===
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==Overview==
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The three-dimensional structure of the haemagglutinin-neuraminidase (HN) from a human parainfluenza virus is described at ca 2.0 A resolution, both in native form and in complex with three substrate analogues. In support of earlier work on the structure of the homologous protein from the avian pathogen Newcastle disease virus (NDV), we observe a dimer of beta-propellers and find no evidence for spatially separated sites performing the receptor-binding and neuraminidase functions of the protein. As with the NDV HN, the active site of the HN of parainfluenza viruses is structurally flexible, suggesting that it may be able to switch between a receptor-binding state and a catalytic state. However, in contrast to the NDV structures, we observe no ligand-induced structural changes that extend beyond the active site and modify the dimer interface.
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The line below this paragraph, {{ABSTRACT_PUBMED_14729348}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 14729348 is the PubMed ID number.
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{{ABSTRACT_PUBMED_14729348}}
==About this Structure==
==About this Structure==
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[[Category: Native+zanamavir]]
[[Category: Native+zanamavir]]
[[Category: Piv3 hn]]
[[Category: Piv3 hn]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 12:01:41 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 19:06:54 2008''

Revision as of 16:07, 28 July 2008

Image:1v3e.png

Template:STRUCTURE 1v3e

Structure of the hemagglutinin-neuraminidase from human parainfluenza virus type III: complex with ZANAMAVIR

Template:ABSTRACT PUBMED 14729348

About this Structure

1V3E is a Single protein structure of sequence from Human parainfluenza virus 3. Full crystallographic information is available from OCA.

Reference

Structure of the haemagglutinin-neuraminidase from human parainfluenza virus type III., Lawrence MC, Borg NA, Streltsov VA, Pilling PA, Epa VC, Varghese JN, McKimm-Breschkin JL, Colman PM, J Mol Biol. 2004 Jan 30;335(5):1343-57. PMID:14729348

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