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1urn

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{{STRUCTURE_1urn| PDB=1urn | SCENE= }}
{{STRUCTURE_1urn| PDB=1urn | SCENE= }}
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'''U1A MUTANT/RNA COMPLEX + GLYCEROL'''
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===U1A MUTANT/RNA COMPLEX + GLYCEROL===
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==Overview==
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The crystal structure of the RNA-binding domain of the small nuclear ribonucleoprotein U1A bound to a 21-nucleotide RNA hairpin has been determined at 1.92 A resolution. The ten-nucleotide RNA loop binds to the surface of the beta-sheet as an open structure, and the AUUGCAC sequence of the loop interacts extensively with the conserved RNP1 and RNP2 motifs and the C-terminal extension of the RNP domain. These interactions include stacking of RNA bases with aromatic side chains of proteins and many direct and water-mediated hydrogen bonds. The structure reveals the stereochemical basis for sequence-specific RNA recognition by the RNP domain.
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{{ABSTRACT_PUBMED_7984237}}
==About this Structure==
==About this Structure==
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[[Category: Protein-rna complex]]
[[Category: Protein-rna complex]]
[[Category: Single strand]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 19:11:08 2008''

Revision as of 16:11, 28 July 2008

Image:1urn.png

Template:STRUCTURE 1urn

U1A MUTANT/RNA COMPLEX + GLYCEROL

Template:ABSTRACT PUBMED 7984237

About this Structure

1URN is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure at 1.92 A resolution of the RNA-binding domain of the U1A spliceosomal protein complexed with an RNA hairpin., Oubridge C, Ito N, Evans PR, Teo CH, Nagai K, Nature. 1994 Dec 1;372(6505):432-8. PMID:7984237

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