1n4x

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{{STRUCTURE_1n4x| PDB=1n4x | SCENE= }}
{{STRUCTURE_1n4x| PDB=1n4x | SCENE= }}
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'''Structure of scFv 1696 at acidic pH'''
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===Structure of scFv 1696 at acidic pH===
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==Overview==
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The monoclonal antibody 1696, which was raised against the HIV-1 protease, inhibits the catalytic activity of the enzyme from both the HIV-1 and HIV-2 strains. The antibody cross-reacts with peptides containing the N-terminus of the enzyme, which is highly conserved between these strains. The crystal structure of a single-chain Fv fragment of 1696 (scFv-1696) in the non-complexed form, solved at 1.7 A resolution, is compared with the previously reported non-complexed Fab-1696 and antigen-bound scFv-1696 structures. Large conformational changes in the third hypervariable region of the heavy chain and differences in relative orientation of the variable domains are observed between the different structures.
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(as it appears on PubMed at http://www.pubmed.gov), where 12777823 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12777823}}
==About this Structure==
==About this Structure==
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[[Category: Sedlacek, J.]]
[[Category: Sedlacek, J.]]
[[Category: Immunoglobulin]]
[[Category: Immunoglobulin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 02:06:03 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 19:38:55 2008''

Revision as of 16:38, 28 July 2008

Image:1n4x.png

Template:STRUCTURE 1n4x

Structure of scFv 1696 at acidic pH

Template:ABSTRACT PUBMED 12777823

About this Structure

1N4X is a Protein complex structure of sequences from Mus musculus. Full crystallographic information is available from OCA.

Reference

Structure of a single-chain Fv fragment of an antibody that inhibits the HIV-1 and HIV-2 proteases., Lescar J, Brynda J, Fabry M, Horejsi M, Rezacova P, Sedlacek J, Bentley GA, Acta Crystallogr D Biol Crystallogr. 2003 May;59(Pt 5):955-7. Epub 2003, Apr 25. PMID:12777823

Page seeded by OCA on Mon Jul 28 19:38:55 2008

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