2dru

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[[Image:2dru.gif|left|200px]]
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{{STRUCTURE_2dru| PDB=2dru | SCENE= }}
{{STRUCTURE_2dru| PDB=2dru | SCENE= }}
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'''Crystal structure and binding properties of the CD2 and CD244 (2B4) binding protein, CD48'''
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===Crystal structure and binding properties of the CD2 and CD244 (2B4) binding protein, CD48===
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==Overview==
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The structural analysis of surface proteins belonging to the CD2 subset of the immunoglobulin superfamily has yielded important insights into transient cellular interactions. In mice and rats, CD2 and CD244 (2B4), which are expressed predominantly on T cells and natural killer cells, respectively, bind the same, broadly expressed ligand, CD48. Structures of CD2 and CD244 have been solved previously, and we now present the structure of the receptor-binding domain of rat CD48. The receptor-binding surface of CD48 is unusually flat, as in the case of rat CD2, and shares a high degree of electrostatic complementarity with the equivalent surface of CD2. The relatively simple arrangement of charged residues and this flat topology explain why CD48 cross-reacts with CD2 and CD244 and, in rats, with the CD244-related protein, 2B4R. Comparisons of modeled complexes of CD2 and CD48 with the complex of human CD2 and CD58 are suggestive of there being substantial plasticity in the topology of ligand binding by CD2. Thermodynamic analysis of the native CD48-CD2 interaction indicates that binding is driven by equivalent, weak enthalpic and entropic effects, in contrast to the human CD2-CD58 interaction, for which there is a large entropic barrier. Overall, the structural and biophysical comparisons of the CD2 homologues suggest that the evolutionary diversification of interacting cell surface proteins is rapid and constrained only by the requirement that binding remains weak and specific.
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(as it appears on PubMed at http://www.pubmed.gov), where 16803907 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16803907}}
==About this Structure==
==About this Structure==
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[[Category: Ikemizu, S.]]
[[Category: Ikemizu, S.]]
[[Category: Cd2 binding domain of cd48]]
[[Category: Cd2 binding domain of cd48]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 01:02:48 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 19:46:42 2008''

Revision as of 16:46, 28 July 2008

Image:2dru.png

Template:STRUCTURE 2dru

Crystal structure and binding properties of the CD2 and CD244 (2B4) binding protein, CD48

Template:ABSTRACT PUBMED 16803907

About this Structure

2DRU is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

Crystal structure and binding properties of the CD2 and CD244 (2B4)-binding protein, CD48., Evans EJ, Castro MA, O'Brien R, Kearney A, Walsh H, Sparks LM, Tucknott MG, Davies EA, Carmo AM, van der Merwe PA, Stuart DI, Jones EY, Ladbury JE, Ikemizu S, Davis SJ, J Biol Chem. 2006 Sep 29;281(39):29309-20. Epub 2006 Jun 27. PMID:16803907

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