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1yns

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[[Image:1yns.gif|left|200px]]
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{{STRUCTURE_1yns| PDB=1yns | SCENE= }}
{{STRUCTURE_1yns| PDB=1yns | SCENE= }}
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'''Crystal Structure Of Human Enolase-phosphatase E1 and its complex with a substrate analog'''
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===Crystal Structure Of Human Enolase-phosphatase E1 and its complex with a substrate analog===
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==Overview==
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Enolase-phosphatase E1 (MASA) is a bifunctional enzyme in the ubiquitous methionine salvage pathway that catalyzes the continuous reactions of 2,3-diketo-5-methylthio-1-phosphopentane to yield the aci-reductone metabolite using Mg2+ as cofactor. In this study, we have determined the crystal structure of MASA and its complex with a substrate analog to 1.7A resolution by multi-wavelength anomalous diffraction and molecular replacement techniques, respectively. The structures support the proposed mechanism of phosphatase activity and further suggest the probable mechanism of enolization. We establish a model for substrate binding to describe in detail the enzymatic reaction and the formation of the transition state, which will provide insight into the reaction mechanisms of other enzymes in the same family.
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(as it appears on PubMed at http://www.pubmed.gov), where 15843022 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15843022}}
==About this Structure==
==About this Structure==
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[[Category: Wang, H.]]
[[Category: Wang, H.]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 16:33:29 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 19:50:42 2008''

Revision as of 16:50, 28 July 2008

Image:1yns.png

Template:STRUCTURE 1yns

Crystal Structure Of Human Enolase-phosphatase E1 and its complex with a substrate analog

Template:ABSTRACT PUBMED 15843022

About this Structure

1YNS is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of human E1 enzyme and its complex with a substrate analog reveals the mechanism of its phosphatase/enolase activity., Wang H, Pang H, Bartlam M, Rao Z, J Mol Biol. 2005 May 13;348(4):917-26. PMID:15843022

Page seeded by OCA on Mon Jul 28 19:50:42 2008

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