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1uhb

From Proteopedia

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[[Image:1uhb.jpg|left|200px]]
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{{STRUCTURE_1uhb| PDB=1uhb | SCENE= }}
{{STRUCTURE_1uhb| PDB=1uhb | SCENE= }}
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'''Crystal structure of porcine alpha trypsin bound with auto catalyticaly produced native peptide at 2.15 A resolution'''
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===Crystal structure of porcine alpha trypsin bound with auto catalyticaly produced native peptide at 2.15 A resolution===
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==Overview==
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Trypsin, a serine protease enzyme plays a pivotal role in digestion and is autocatalytic. The crystal structure of a complex formed between porcine trypsin and an auto catalytically produced peptide is reported here. This complex shows a reduction in enzyme activity as compared to native beta-trypsin. The nonapeptide has a lysine, which is recognized by Asp 189 at the specificity pocket. The auto catalytically produced native nonapeptide is bound at the active site cleft like other trypsin inhibitors but the important interactions with the oxyanion hole are absent. The peptide covers only a part of the active site cleft and hence the enzyme activity is reduced rather than being inhibited.
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The line below this paragraph, {{ABSTRACT_PUBMED_15106996}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 15106996 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15106996}}
==About this Structure==
==About this Structure==
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==Reference==
==Reference==
Trypsin activity reduced by an autocatalytically produced nonapeptide., Ibrahim BS, Shamaladevi N, Pattabhi V, J Biomol Struct Dyn. 2004 Jun;21(6):737-44. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15106996 15106996]
Trypsin activity reduced by an autocatalytically produced nonapeptide., Ibrahim BS, Shamaladevi N, Pattabhi V, J Biomol Struct Dyn. 2004 Jun;21(6):737-44. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15106996 15106996]
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Crystal structure at 1.63 A resolution of the native form of porcine beta-trypsin: revealing an acetate ion binding site and functional water network., Johnson A, Gautham N, Pattabhi V, Biochim Biophys Acta. 1999 Nov 16;1435(1-2):7-21. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10561533 10561533]
[[Category: Protein complex]]
[[Category: Protein complex]]
[[Category: Sus scrofa]]
[[Category: Sus scrofa]]
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[[Category: Peptide trypsin complex]]
[[Category: Peptide trypsin complex]]
[[Category: Serine protease]]
[[Category: Serine protease]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 11:13:45 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 19:51:57 2008''

Revision as of 16:52, 28 July 2008

Image:1uhb.png

Template:STRUCTURE 1uhb

Crystal structure of porcine alpha trypsin bound with auto catalyticaly produced native peptide at 2.15 A resolution

Template:ABSTRACT PUBMED 15106996

About this Structure

1UHB is a Protein complex structure of sequences from Sus scrofa. Full crystallographic information is available from OCA.

Reference

Trypsin activity reduced by an autocatalytically produced nonapeptide., Ibrahim BS, Shamaladevi N, Pattabhi V, J Biomol Struct Dyn. 2004 Jun;21(6):737-44. PMID:15106996

Crystal structure at 1.63 A resolution of the native form of porcine beta-trypsin: revealing an acetate ion binding site and functional water network., Johnson A, Gautham N, Pattabhi V, Biochim Biophys Acta. 1999 Nov 16;1435(1-2):7-21. PMID:10561533

Page seeded by OCA on Mon Jul 28 19:51:57 2008

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