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1n3k

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[[Image:1n3k.jpg|left|200px]]
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{{STRUCTURE_1n3k| PDB=1n3k | SCENE= }}
{{STRUCTURE_1n3k| PDB=1n3k | SCENE= }}
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'''Solution structure of phosphoprotein enriched in astrocytes 15 kDa (PEA-15)'''
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===Solution structure of phosphoprotein enriched in astrocytes 15 kDa (PEA-15)===
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==Overview==
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PEA-15 is a multifunctional protein that modulates signaling pathways which control cell proliferation and cell death. In particular, PEA-15 regulates the actions of the ERK MAP kinase cascade by binding to ERK and altering its subcellular localization. The three-dimensional structure of PEA-15 has been determined using NMR spectroscopy and its interaction with ERK defined by characterization of mutants that modulate ERK function. PEA-15 is composed of an N-terminal death effector domain (DED) and a C-terminal tail of irregular structure. NMR 'footprinting' and mutagenesis identified elements of both the DED and tail that are required for ERK binding. Comparison of the DED-binding surface for ERK2 with the death domain (DD)-binding surface of Drosophila Tube revealed an unexpected similarity between the interaction modes of the DD and DED motifs in these proteins. Despite a lack of functional or sequence similarity between PEA-15 and Tube, these proteins utilize a common surface of the structurally similar DD and DED to recognize functionally diverse targets.
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The line below this paragraph, {{ABSTRACT_PUBMED_12456656}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 12456656 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12456656}}
==About this Structure==
==About this Structure==
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1N3K is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Cricetulus_griseus Cricetulus griseus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N3K OCA].
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1N3K is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Cricetulus_griseus Cricetulus griseus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N3K OCA].
==Reference==
==Reference==
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[[Category: Death effector domain]]
[[Category: Death effector domain]]
[[Category: Six helix bundle]]
[[Category: Six helix bundle]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 02:02:45 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 20:15:08 2008''

Revision as of 17:15, 28 July 2008

Image:1n3k.png

Template:STRUCTURE 1n3k

Solution structure of phosphoprotein enriched in astrocytes 15 kDa (PEA-15)

Template:ABSTRACT PUBMED 12456656

About this Structure

1N3K is a Single protein structure of sequence from Cricetulus griseus. Full experimental information is available from OCA.

Reference

Recognition of ERK MAP kinase by PEA-15 reveals a common docking site within the death domain and death effector domain., Hill JM, Vaidyanathan H, Ramos JW, Ginsberg MH, Werner MH, EMBO J. 2002 Dec 2;21(23):6494-504. PMID:12456656

Page seeded by OCA on Mon Jul 28 20:15:08 2008

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