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1uus

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[[Image:1uus.jpg|left|200px]]
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[[Image:1uus.png|left|200px]]
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{{STRUCTURE_1uus| PDB=1uus | SCENE= }}
{{STRUCTURE_1uus| PDB=1uus | SCENE= }}
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'''STRUCTURE OF AN ACTIVATED DICTYOSTELIUM STAT IN ITS DNA-UNBOUND FORM'''
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===STRUCTURE OF AN ACTIVATED DICTYOSTELIUM STAT IN ITS DNA-UNBOUND FORM===
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==Overview==
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Dd-STATa is a STAT protein which transcriptionally regulates cellular differentiation in Dictyostelium discoideum, the only non-metazoan known to employ SH2 domain signaling. The 2.7 A crystal structure of a tyrosine phosphorylated Dd-STATa homodimer reveals a four-domain architecture similar to that of mammalian STATs 1 and 3, but with an inverted orientation for the coiled-coil domain. Dimerization is mediated by SH2 domain:phosphopeptide interactions and by a direct interaction between SH2 domains. The unliganded Dd-STATa dimer adopts a fully extended conformation remarkably different from that of the DNA-bound mammalian STATs, implying a large conformational change upon target site recognition. Buried hydrophilic residues predicted to destabilize the coiled-coil domain suggest how hydrophobic residues may become exposed and mediate nuclear export. Functional and evolutionary implications for metazoan STAT proteins are discussed.
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The line below this paragraph, {{ABSTRACT_PUBMED_15053873}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 15053873 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15053873}}
==About this Structure==
==About this Structure==
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[[Category: Transcription factor]]
[[Category: Transcription factor]]
[[Category: Transducer]]
[[Category: Transducer]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 11:43:23 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 20:22:00 2008''

Revision as of 17:22, 28 July 2008

Image:1uus.png

Template:STRUCTURE 1uus

STRUCTURE OF AN ACTIVATED DICTYOSTELIUM STAT IN ITS DNA-UNBOUND FORM

Template:ABSTRACT PUBMED 15053873

About this Structure

1UUS is a Single protein structure of sequence from Dictyostelium discoideum. Full crystallographic information is available from OCA.

Reference

Structure of an activated Dictyostelium STAT in its DNA-unbound form., Soler-Lopez M, Petosa C, Fukuzawa M, Ravelli R, Williams JG, Muller CW, Mol Cell. 2004 Mar 26;13(6):791-804. PMID:15053873

Page seeded by OCA on Mon Jul 28 20:22:00 2008

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