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1u5w

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[[Image:1u5w.gif|left|200px]]
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{{STRUCTURE_1u5w| PDB=1u5w | SCENE= }}
{{STRUCTURE_1u5w| PDB=1u5w | SCENE= }}
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'''Crystal structure of hypothetical protein yjjX from Escherichia coli'''
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===Crystal structure of hypothetical protein yjjX from Escherichia coli===
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==Overview==
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Inosine triphosphate (ITP) and xanthosine triphosphate (XTP) are formed upon deamination of ATP and GTP as a result of exposure to chemical mutagens and oxidative damage. Nucleic acid synthesis requires safeguard mechanisms to minimize undesired lethal incorporation of ITP and XTP. Here, we present the crystal structure of YjjX, a protein of hitherto unknown function. The three-dimensional fold of YjjX is similar to those of Mj0226 from Methanococcus janschii, which possesses nucleotidase activity, and of Maf from Bacillus subtilis, which can bind nucleotides. Biochemical analyses of YjjX revealed it to exhibit specific phosphatase activity for inosine and xanthosine triphosphates and have a possible interaction with elongation factor Tu. The enzymatic activity of YjjX as an inosine/xanthosine triphosphatase provides evidence for a plausible protection mechanism by clearing the noncanonical nucleotides from the cell during oxidative stress in E. coli.
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The line below this paragraph, {{ABSTRACT_PUBMED_16216582}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 16216582 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16216582}}
==About this Structure==
==About this Structure==
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[[Category: Montreal-kingston bacterial structural genomics initiative]]
[[Category: Montreal-kingston bacterial structural genomics initiative]]
[[Category: Structural genomic]]
[[Category: Structural genomic]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 10:47:35 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 20:23:29 2008''

Revision as of 17:23, 28 July 2008

Image:1u5w.png

Template:STRUCTURE 1u5w

Crystal structure of hypothetical protein yjjX from Escherichia coli

Template:ABSTRACT PUBMED 16216582

About this Structure

1U5W is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Identification of an ITPase/XTPase in Escherichia coli by structural and biochemical analysis., Zheng J, Singh VK, Jia Z, Structure. 2005 Oct;13(10):1511-20. PMID:16216582

Page seeded by OCA on Mon Jul 28 20:23:29 2008

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