1pd7

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{{STRUCTURE_1pd7| PDB=1pd7 | SCENE= }}
{{STRUCTURE_1pd7| PDB=1pd7 | SCENE= }}
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'''Extended SID of Mad1 bound to the PAH2 domain of mSin3B'''
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===Extended SID of Mad1 bound to the PAH2 domain of mSin3B===
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==Overview==
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Sin3 forms the scaffold for a multiprotein corepressor complex that silences transcription via the action of histone deacetylases. Sin3 is recruited to the DNA by several DNA binding repressors, such as the helix-loop-helix proteins of the Mad family. Here, we elaborate on the Mad-Sin3 interaction based on a binding study, solution structure, and dynamics of the PAH2 domain of mSin3 in complex to an extended Sin3 interacting domain (SID) of 24 residues of Mad1. We show that SID residues Met7 and Glu23, outside the previously defined minimal binding motif, mediate additional hydrophobic and electrostatic interactions with PAH2. On the basis of these results we propose an extended consensus sequence describing the PAH2-SID interaction specifically for the Mad family, showing that residues outside the hydrophobic core of the SID interact with PAH2 and modulate binding affinity to appropriate levels.
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{{ABSTRACT_PUBMED_14705930}}
==About this Structure==
==About this Structure==
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1PD7 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PD7 OCA].
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1PD7 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PD7 OCA].
==Reference==
==Reference==
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[[Category: Protein-protein interaction]]
[[Category: Protein-protein interaction]]
[[Category: Sin3]]
[[Category: Sin3]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 20:24:19 2008''

Revision as of 17:24, 28 July 2008

Image:1pd7.png

Template:STRUCTURE 1pd7

Extended SID of Mad1 bound to the PAH2 domain of mSin3B

Template:ABSTRACT PUBMED 14705930

About this Structure

1PD7 is a Protein complex structure of sequences from Mus musculus. Full experimental information is available from OCA.

Reference

Extension of the binding motif of the Sin3 interacting domain of the Mad family proteins., van Ingen H, Lasonder E, Jansen JF, Kaan AM, Spronk CA, Stunnenberg HG, Vuister GW, Biochemistry. 2004 Jan 13;43(1):46-54. PMID:14705930

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