2jon

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[[Image:2jon.jpg|left|200px]]
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[[Image:2jon.png|left|200px]]
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{{STRUCTURE_2jon| PDB=2jon | SCENE= }}
{{STRUCTURE_2jon| PDB=2jon | SCENE= }}
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'''Solution structure of the C-terminal domain Ole e 9'''
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===Solution structure of the C-terminal domain Ole e 9===
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==Overview==
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Ole e 9 is an olive pollen allergen belonging to group 2 of pathogenesis-related proteins. The protein is composed of two immunological independent domains: an N-terminal domain (NtD) with 1,3-beta-glucanase activity, and a C-terminal domain (CtD) that binds 1,3-beta-glucans. We have determined the three-dimensional structure of CtD-Ole e 9 (101 amino acids), which consists of two parallel alpha-helices forming an angle of approximately 55 degrees , a small antiparallel beta-sheet with two short strands, and a 3-10 helix turn, all connected by long coil segments, resembling a novel type of folding among allergens. Two regions surrounded by aromatic residues (F49, Y60, F96, Y91 and Y31, H68, Y65, F78) have been localized on the protein surface, and a role for sugar binding is suggested. The epitope mapping of CtD-Ole e 9 shows that B-cell epitopes are mainly located on loops, although some of them are contained in secondary structural elements. Interestingly, the IgG and IgE epitopes are contiguous or overlapped, rather than coincident. The three-dimensional structure of CtD-Ole e 9 might help to understand the underlying mechanism of its biochemical function and to determine possible structure-allergenicity relationships.
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The line below this paragraph, {{ABSTRACT_PUBMED_18096638}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 18096638 is the PubMed ID number.
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{{ABSTRACT_PUBMED_18096638}}
==About this Structure==
==About this Structure==
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JON OCA].
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Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JON OCA].
==Reference==
==Reference==
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[[Category: Allergen]]
[[Category: Allergen]]
[[Category: Olive pollen]]
[[Category: Olive pollen]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 09:07:16 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 20:35:59 2008''

Revision as of 17:36, 28 July 2008

Image:2jon.png

Template:STRUCTURE 2jon

Solution structure of the C-terminal domain Ole e 9

Template:ABSTRACT PUBMED 18096638

About this Structure

Full experimental information is available from OCA.

Reference

Solution structure of the C-terminal domain of Ole e 9, a major allergen of olive pollen., Trevino MA, Palomares O, Castrillo I, Villalba M, Rodriguez R, Rico M, Santoro J, Bruix M, Protein Sci. 2008 Feb;17(2):371-6. Epub 2007 Dec 20. PMID:18096638

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