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1tzo

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[[Image:1tzo.gif|left|200px]]
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{{STRUCTURE_1tzo| PDB=1tzo | SCENE= }}
{{STRUCTURE_1tzo| PDB=1tzo | SCENE= }}
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'''Crystal Structure of the Anthrax Toxin Protective Antigen Heptameric Prepore'''
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===Crystal Structure of the Anthrax Toxin Protective Antigen Heptameric Prepore===
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==Overview==
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After binding to cellular receptors and proteolytic activation, the protective antigen component of anthrax toxin forms a heptameric prepore. The prepore later undergoes pH-dependent conversion to a pore, mediating translocation of the edema and lethal factors to the cytosol. We describe structures of the prepore (3.6 A) and a prepore:receptor complex (4.3 A) that reveal the location of pore-forming loops and an unexpected interaction of the receptor with the pore-forming domain. Lower pH is required for prepore-to-pore conversion in the presence of the receptor, indicating that this interaction regulates pH-dependent pore formation. We present an example of a receptor negatively regulating pH-dependent membrane insertion.
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{{ABSTRACT_PUBMED_15326297}}
==About this Structure==
==About this Structure==
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[[Category: Wigelsworth, D J.]]
[[Category: Wigelsworth, D J.]]
[[Category: Heptamer]]
[[Category: Heptamer]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 10:33:56 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 20:38:30 2008''

Revision as of 17:38, 28 July 2008

Image:1tzo.png

Template:STRUCTURE 1tzo

Crystal Structure of the Anthrax Toxin Protective Antigen Heptameric Prepore

Template:ABSTRACT PUBMED 15326297

About this Structure

1TZO is a Single protein structure of sequence from Bacillus anthracis. Full crystallographic information is available from OCA.

Reference

Structure of heptameric protective antigen bound to an anthrax toxin receptor: a role for receptor in pH-dependent pore formation., Lacy DB, Wigelsworth DJ, Melnyk RA, Harrison SC, Collier RJ, Proc Natl Acad Sci U S A. 2004 Sep 7;101(36):13147-51. Epub 2004 Aug 23. PMID:15326297

Page seeded by OCA on Mon Jul 28 20:38:30 2008

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