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1tz3

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{{STRUCTURE_1tz3| PDB=1tz3 | SCENE= }}
{{STRUCTURE_1tz3| PDB=1tz3 | SCENE= }}
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'''crystal structure of aminoimidazole riboside kinase complexed with aminoimidazole riboside'''
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===crystal structure of aminoimidazole riboside kinase complexed with aminoimidazole riboside===
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==Overview==
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The crystal structures of a Salmonella enterica aminoimidazole riboside (AIRs) kinase, its complex with the substrate AIRs, and its complex with AIRs and an ATP analog were determined at 2.6 angstroms, 2.9 angstroms, and 2.7 angstroms, respectively. The product of the Salmonella-specific gene stm4066, AIRs kinase, is a homodimer with one active site per monomer. The core structure, consisting of an eight-stranded beta sheet flanked by eight alpha helices, indicates that AIRs kinase is a member of the ribokinase superfamily. Unlike ribokinase and adenosine kinase in this superfamily, AIRs kinase does not show significant conformational changes upon substrate binding. The active site is covered by a lid formed by residues 16-28 and 86-100. A comparison of the structure of AIRs kinase with other ribokinase superfamily members suggests that the active site lid and conformational changes that occur upon substrate binding may be advanced features in the evolution of the ribokinase superfamily.
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The line below this paragraph, {{ABSTRACT_PUBMED_15458630}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 15458630 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15458630}}
==About this Structure==
==About this Structure==
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[[Category: Alpha/beta]]
[[Category: Alpha/beta]]
[[Category: Ribokinase fold]]
[[Category: Ribokinase fold]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 10:32:34 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 20:57:33 2008''

Revision as of 17:57, 28 July 2008

Image:1tz3.png

Template:STRUCTURE 1tz3

crystal structure of aminoimidazole riboside kinase complexed with aminoimidazole riboside

Template:ABSTRACT PUBMED 15458630

About this Structure

1TZ3 is a Single protein structure of sequence from Salmonella typhimurium lt2. Full crystallographic information is available from OCA.

Reference

Crystal structure of an aminoimidazole riboside kinase from Salmonella enterica: implications for the evolution of the ribokinase superfamily., Zhang Y, Dougherty M, Downs DM, Ealick SE, Structure. 2004 Oct;12(10):1809-21. PMID:15458630

Page seeded by OCA on Mon Jul 28 20:57:33 2008

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