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2ozo

From Proteopedia

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[[Image:2ozo.jpg|left|200px]]
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{{STRUCTURE_2ozo| PDB=2ozo | SCENE= }}
{{STRUCTURE_2ozo| PDB=2ozo | SCENE= }}
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'''Autoinhibited intact human ZAP-70'''
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===Autoinhibited intact human ZAP-70===
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==Overview==
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ZAP-70, a cytoplasmic tyrosine kinase required for T cell antigen receptor signaling, is controlled by a regulatory segment that includes a tandem SH2 unit responsible for binding to immunoreceptor tyrosine-based activation motifs (ITAMs). The crystal structure of autoinhibited ZAP-70 reveals that the inactive kinase domain adopts a conformation similar to that of cyclin-dependent kinases and Src kinases. The autoinhibitory mechanism of ZAP-70 is, however, distinct and involves interactions between the regulatory segment and the hinge region of the kinase domain that reduce its flexibility. Two tyrosine residues in the SH2-kinase linker that activate ZAP-70 when phosphorylated are involved in aromatic-aromatic interactions that connect the linker to the kinase domain. These interactions are inconsistent with ITAM binding, suggesting that destabilization of this autoinhibited ZAP-70 conformation is the first step in kinase activation.
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(as it appears on PubMed at http://www.pubmed.gov), where 17512407 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17512407}}
==About this Structure==
==About this Structure==
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[[Category: Tandem sh2]]
[[Category: Tandem sh2]]
[[Category: Tcr signaling]]
[[Category: Tcr signaling]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 12:00:24 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 20:58:18 2008''

Revision as of 17:58, 28 July 2008

Image:2ozo.png

Template:STRUCTURE 2ozo

Autoinhibited intact human ZAP-70

Template:ABSTRACT PUBMED 17512407

About this Structure

2OZO is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structural basis for the inhibition of tyrosine kinase activity of ZAP-70., Deindl S, Kadlecek TA, Brdicka T, Cao X, Weiss A, Kuriyan J, Cell. 2007 May 18;129(4):735-46. PMID:17512407

Page seeded by OCA on Mon Jul 28 20:58:18 2008

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