1odb

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{{STRUCTURE_1odb| PDB=1odb | SCENE= }}
{{STRUCTURE_1odb| PDB=1odb | SCENE= }}
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'''THE CRYSTAL STRUCTURE OF HUMAN S100A12- COPPER COMPLEX'''
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===THE CRYSTAL STRUCTURE OF HUMAN S100A12- COPPER COMPLEX===
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==Overview==
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S100A12 is a member of the S100 family of EF-hand calcium-modulated proteins. Together with S100A8 and S100A9, it belongs to the calgranulin subfamily, i.e. it is mainly expressed in granulocytes, although there is an increasing body of evidence of expression in keratinocytes and psoriatic lesions. As well as being linked to inflammation, allergy and neuritogenesis, S100A12 is involved in host-parasite response, as are the other two calgranulins. Recent data suggest that the function of the S100-family proteins is modulated not only by calcium, but also by other metals such as zinc and copper. Previously, the structure of human S100A12 in low-calcium and high-calcium structural forms, crystallized in space groups R3 and P2(1), respectively, has been reported. Here, the structure of S100A12 in complex with copper (space group P2(1)2(1)2; unit-cell parameters a = 70.6, b = 119.0, c = 90.2 A) refined at 2.19 A resolution is reported. Comparison of anomalous difference electron-density maps calculated with data collected with radiation of wavelengths 1.37 and 1.65 A shows that each monomer binds a single copper ion. The copper binds at an equivalent site to that at which another S100 protein, S100A7, binds zinc. The results suggest that copper binding may be essential for the functional role of S100A12 and probably the other calgranulins in the early immune response.
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(as it appears on PubMed at http://www.pubmed.gov), where 12777802 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12777802}}
==About this Structure==
==About this Structure==
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[[Category: S100 protein]]
[[Category: S100 protein]]
[[Category: X-ray structure]]
[[Category: X-ray structure]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 03:41:56 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 21:05:50 2008''

Revision as of 18:05, 28 July 2008

Image:1odb.png

Template:STRUCTURE 1odb

THE CRYSTAL STRUCTURE OF HUMAN S100A12- COPPER COMPLEX

Template:ABSTRACT PUBMED 12777802

About this Structure

1ODB is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure of the human S100A12-copper complex: implications for host-parasite defence., Moroz OV, Antson AA, Grist SJ, Maitland NJ, Dodson GG, Wilson KS, Lukanidin E, Bronstein IB, Acta Crystallogr D Biol Crystallogr. 2003 May;59(Pt 5):859-67. Epub 2003, Apr 25. PMID:12777802

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