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2bb5

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{{STRUCTURE_2bb5| PDB=2bb5 | SCENE= }}
{{STRUCTURE_2bb5| PDB=2bb5 | SCENE= }}
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'''Structure of Human Transcobalamin in complex with Cobalamin'''
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===Structure of Human Transcobalamin in complex with Cobalamin===
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==Overview==
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Cobalamin (Cbl, vitamin B(12)) serves for two essential cofactors in mammals. The pathway for its intestinal absorption, plasma transport, and cellular uptake uses cell surface receptors and three Cbl-transporting proteins, haptocorrin, intrinsic factor, and transcobalamin (TC). We present the structure determination of a member of the mammalian Cbl-transporter family. The crystal structures of recombinant human and bovine holo-TCs reveal a two-domain architecture, with an N-terminal alpha(6)-alpha(6) barrel and a smaller C-terminal domain. One Cbl molecule in base-on conformation is buried inside the domain interface. Structural data combined with previous binding assays indicate a domain motion in the first step of Cbl binding. In a second step, the weakly coordinated ligand H(2)O at the upper axial side of added H(2)O-Cbl is displaced by a histidine residue of the alpha(6)-alpha(6) barrel. Analysis of amino acid conservation on TC's surface in orthologous proteins suggests the location of the TC-receptor-recognition site in an extended region on the alpha(6)-alpha(6) barrel. The TC structure allows for the mapping of sites of amino acid variation due to polymorphisms of the human TC gene. Structural information is used to predict the overall fold of haptocorrin and intrinsic factor and permits a rational approach to the design of new Cbl-based bioconjugates for diagnostic or therapeutic drug delivery.
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{{ABSTRACT_PUBMED_16537422}}
==About this Structure==
==About this Structure==
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[[Category: Wuerges, J.]]
[[Category: Wuerges, J.]]
[[Category: Alpha_6 - alpha_6 barrel]]
[[Category: Alpha_6 - alpha_6 barrel]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 20:03:46 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 21:31:23 2008''

Revision as of 18:31, 28 July 2008

Image:2bb5.png

Template:STRUCTURE 2bb5

Structure of Human Transcobalamin in complex with Cobalamin

Template:ABSTRACT PUBMED 16537422

About this Structure

2BB5 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structural basis for mammalian vitamin B12 transport by transcobalamin., Wuerges J, Garau G, Geremia S, Fedosov SN, Petersen TE, Randaccio L, Proc Natl Acad Sci U S A. 2006 Mar 21;103(12):4386-91. Epub 2006 Mar 14. PMID:16537422

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