1vqq

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{{Seed}}
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{{STRUCTURE_1vqq| PDB=1vqq | SCENE= }}
{{STRUCTURE_1vqq| PDB=1vqq | SCENE= }}
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'''Structure of Penicillin binding protein 2a from methicillin resistant Staphylococcus aureus strain 27r at 1.80 A resolution.'''
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===Structure of Penicillin binding protein 2a from methicillin resistant Staphylococcus aureus strain 27r at 1.80 A resolution.===
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==Overview==
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The multiple antibiotic resistance of methicillin-resistant strains of Staphylococcus aureus (MRSA) has become a major clinical problem worldwide. The key determinant of the broad-spectrum beta-lactam resistance in MRSA strains is the penicillin-binding protein 2a (PBP2a). Because of its low affinity for beta-lactams, PBP2a provides transpeptidase activity to allow cell wall synthesis at beta-lactam concentrations that inhibit the beta-lactam-sensitive PBPs normally produced by S. aureus. The crystal structure of a soluble derivative of PBP2a has been determined to 1.8 A resolution and provides the highest resolution structure for a high molecular mass PBP. Additionally, structures of the acyl-PBP complexes of PBP2a with nitrocefin, penicillin G and methicillin allow, for the first time, a comparison of an apo and acylated resistant PBP. An analysis of the PBP2a active site in these forms reveals the structural basis of its resistance and identifies features in newly developed beta-lactams that are likely important for high affinity binding.
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The line below this paragraph, {{ABSTRACT_PUBMED_12389036}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 12389036 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12389036}}
==About this Structure==
==About this Structure==
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[[Category: D,d-transpeptidase]]
[[Category: D,d-transpeptidase]]
[[Category: Penicillin binding protein]]
[[Category: Penicillin binding protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 12:48:24 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 21:33:53 2008''

Revision as of 18:33, 28 July 2008

Image:1vqq.png

Template:STRUCTURE 1vqq

Structure of Penicillin binding protein 2a from methicillin resistant Staphylococcus aureus strain 27r at 1.80 A resolution.

Template:ABSTRACT PUBMED 12389036

About this Structure

This structure supersedes the now removed PDB entry 1mwx. Full crystallographic information is available from OCA.

Reference

Structural basis for the beta lactam resistance of PBP2a from methicillin-resistant Staphylococcus aureus., Lim D, Strynadka NC, Nat Struct Biol. 2002 Nov;9(11):870-6. PMID:12389036

Page seeded by OCA on Mon Jul 28 21:33:53 2008

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