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1t7s

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{{STRUCTURE_1t7s| PDB=1t7s | SCENE= }}
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'''Structural Genomics of Caenorhabditis elegans: Structure of BAG-1 protein'''
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===Structural Genomics of Caenorhabditis elegans: Structure of BAG-1 protein===
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==Overview==
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Binding of the BAG domain to the eukaryotic chaperone heat-shock protein (Hsp70) promotes ATP-dependent release of the protein substrate from Hsp70. Although the murine and human BAG domains have been shown to form an antiparallel three-helix bundle, the Caenorhabditis elegans BAG domain is formed by two antiparallel helices, while the third helix is extended away and stabilized by crystal-packing interactions. A small beta-sheet between helices 2 and 3 interferes with formation of the intramolecular three-helix bundle. However, intermolecular three-helix bundles are observed throughout the crystal packing and suggest that stable functional dimers and tetramers can be formed in solution. The structure may represent a new folding type of the BAG domain.
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(as it appears on PubMed at http://www.pubmed.gov), where 15333932 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15333932}}
==About this Structure==
==About this Structure==
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[[Category: Southeast collaboratory for structural genomic]]
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[[Category: Structural genomic]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 09:38:32 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 21:44:44 2008''

Revision as of 18:44, 28 July 2008

Image:1t7s.png

Template:STRUCTURE 1t7s

Structural Genomics of Caenorhabditis elegans: Structure of BAG-1 protein

Template:ABSTRACT PUBMED 15333932

About this Structure

1T7S is a Single protein structure of sequence from Caenorhabditis elegans. Full crystallographic information is available from OCA.

Reference

Structural genomics of Caenorhabditis elegans: structure of the BAG domain., Symersky J, Zhang Y, Schormann N, Li S, Bunzel R, Pruett P, Luan CH, Luo M, Acta Crystallogr D Biol Crystallogr. 2004 Sep;60(Pt 9):1606-10. Epub 2004, Aug 26. PMID:15333932

Page seeded by OCA on Mon Jul 28 21:44:44 2008

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