1s8c

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{{STRUCTURE_1s8c| PDB=1s8c | SCENE= }}
{{STRUCTURE_1s8c| PDB=1s8c | SCENE= }}
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'''Crystal structure of human heme oxygenase in a complex with biliverdine'''
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===Crystal structure of human heme oxygenase in a complex with biliverdine===
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==Overview==
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Heme oxygenase oxidatively cleaves heme to biliverdin, leading to the release of iron and CO through a process in which the heme participates both as a cofactor and as a substrate. Here we report the crystal structure of the product, iron-free biliverdin, in a complex with human HO-1 at 2.19 A. Structural comparisons of the human biliverdin-HO-1 structure with its heme complex and the recently published rat HO-1 structure in a complex with the biliverdin-iron chelate [Sugishima, M., Sakamoto, H., Higashimoto, Y., Noguchi, M., and Fukuyama, K. (2003) J. Biol. Chem. 278, 32352-32358] show two major differences. First, in the absence of an Fe-His bond and solvent structure in the active site, the distal and proximal helices relax and adopt an "open" conformation which most likely encourages biliverdin release. Second, iron-free biliverdin occupies a different position and orientation relative to heme and the biliverdin-iron complex. Biliverdin adopts a more linear conformation and moves from the heme site to an internal cavity. These structural results provide insight into the rate-limiting step in HO-1 catalysis, which is product, biliverdin, release.
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The line below this paragraph, {{ABSTRACT_PUBMED_15049686}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 15049686 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15049686}}
==About this Structure==
==About this Structure==
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[[Category: Heme degradation]]
[[Category: Heme degradation]]
[[Category: Heme oxygenase-1]]
[[Category: Heme oxygenase-1]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 08:25:25 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 22:46:02 2008''

Revision as of 19:46, 28 July 2008

Image:1s8c.png

Template:STRUCTURE 1s8c

Crystal structure of human heme oxygenase in a complex with biliverdine

Template:ABSTRACT PUBMED 15049686

About this Structure

1S8C is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of human heme oxygenase-1 in a complex with biliverdin., Lad L, Friedman J, Li H, Bhaskar B, Ortiz de Montellano PR, Poulos TL, Biochemistry. 2004 Apr 6;43(13):3793-801. PMID:15049686

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