1vfx

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[[Image:1vfx.gif|left|200px]]
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{{Seed}}
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{{STRUCTURE_1vfx| PDB=1vfx | SCENE= }}
{{STRUCTURE_1vfx| PDB=1vfx | SCENE= }}
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'''Crystal Structure of the Kif1A Motor Domain Complexed With ADP-Mg-AlFx'''
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===Crystal Structure of the Kif1A Motor Domain Complexed With ADP-Mg-AlFx===
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==Overview==
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The motor protein kinesin moves along microtubules, driven by adenosine triphosphate (ATP) hydrolysis. However, it remains unclear how kinesin converts the chemical energy into mechanical movement. We report crystal structures of monomeric kinesin KIF1A with three transition-state analogs: adenylyl imidodiphosphate (AMP-PNP), adenosine diphosphate (ADP)-vanadate, and ADP-AlFx (aluminofluoride complexes). These structures, together with known structures of the ADP-bound state and the adenylyl-(beta,gamma-methylene) diphosphate (AMP-PCP)-bound state, show that kinesin uses two microtubule-binding loops in an alternating manner to change its interaction with microtubules during the ATP hydrolysis cycle; loop L11 is extended in the AMP-PNP structure, whereas loop L12 is extended in the ADP structure. ADP-vanadate displays an intermediate structure in which a conformational change in two switch regions causes both loops to be raised from the microtubule, thus actively detaching kinesin.
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The line below this paragraph, {{ABSTRACT_PUBMED_15286375}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 15286375 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15286375}}
==About this Structure==
==About this Structure==
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[[Category: Microtubule]]
[[Category: Microtubule]]
[[Category: Motor]]
[[Category: Motor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 12:29:53 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 22:48:16 2008''

Revision as of 19:48, 28 July 2008

Image:1vfx.png

Template:STRUCTURE 1vfx

Crystal Structure of the Kif1A Motor Domain Complexed With ADP-Mg-AlFx

Template:ABSTRACT PUBMED 15286375

About this Structure

1VFX is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

KIF1A alternately uses two loops to bind microtubules., Nitta R, Kikkawa M, Okada Y, Hirokawa N, Science. 2004 Jul 30;305(5684):678-83. PMID:15286375

Page seeded by OCA on Mon Jul 28 22:48:16 2008

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