2jp8

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{{STRUCTURE_2jp8| PDB=2jp8 | SCENE= }}
{{STRUCTURE_2jp8| PDB=2jp8 | SCENE= }}
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'''Angiotensin 1-7'''
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===Angiotensin 1-7===
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==Overview==
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We report the complete sequence-specific hydrogen NMR assignments of vasoactive peptide angiotensin-(1-7) (Ang-(1-7)). Assignments of the majority of the resonances were accomplished by COSY, TOCSY, and ROESY peak coordinates at 400MHz and 600MHz. Long-side-chain amino acid spin system identification was facilitated by long-range coherence transfer experiments (TOCSY). Problems with overlapped resonance signals were solved by analysis of heteronuclear 2D experiments (HSQC and HMBC). Nuclear Overhauser effects (NOE) results were used to probe peptide conformation. We show that the inclusion of the angiotensin-(1-7) tyrosine residue is favored in inclusion complexes with beta-cyclodextrin. QM/MM simulations at the DFTB/UFF level confirm the experimental NMR findings and provide detailed structural information on these compounds in aqueous solution.
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(as it appears on PubMed at http://www.pubmed.gov), where 17904691 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17904691}}
==About this Structure==
==About this Structure==
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2JP8 is a [[Single protein]] structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JP8 OCA].
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2JP8 is a [[Single protein]] structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JP8 OCA].
==Reference==
==Reference==
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[[Category: Bend]]
[[Category: Bend]]
[[Category: Signaling protein]]
[[Category: Signaling protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 09:08:33 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 23:23:07 2008''

Revision as of 20:23, 28 July 2008

Image:2jp8.png

Template:STRUCTURE 2jp8

Angiotensin 1-7

Template:ABSTRACT PUBMED 17904691

About this Structure

2JP8 is a Single protein structure. Full experimental information is available from OCA.

Reference

Study of angiotensin-(1-7) vasoactive peptide and its beta-cyclodextrin inclusion complexes: complete sequence-specific NMR assignments and structural studies., Lula I, Denadai AL, Resende JM, de Sousa FB, de Lima GF, Pilo-Veloso D, Heine T, Duarte HA, Santos RA, Sinisterra RD, Peptides. 2007 Nov;28(11):2199-210. Epub 2007 Aug 19. PMID:17904691

Page seeded by OCA on Mon Jul 28 23:23:07 2008

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