1ya0

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[[Image:1ya0.gif|left|200px]]
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{{Seed}}
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{{STRUCTURE_1ya0| PDB=1ya0 | SCENE= }}
{{STRUCTURE_1ya0| PDB=1ya0 | SCENE= }}
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'''Crystal structure of the N-terminal domain of human SMG7'''
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===Crystal structure of the N-terminal domain of human SMG7===
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==Overview==
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In metazoa, regulation of the phosphorylation state of UPF1 is crucial for nonsense-mediated mRNA decay (NMD), a process by which aberrant mRNAs containing nonsense mutations are degraded. UPF1 is targeted for dephosphorylation by three related proteins, SMG5, SMG6, and SMG7. We report here the crystal structure of the N-terminal domain of SMG7. The structure reveals that SMG7 contains a 14-3-3-like domain. Residues that bind phosphoserine-containing peptides in 14-3-3 are conserved at the equivalent positions in SMG7. Mutation of these residues impairs UPF1 binding to SMG7 in vitro and UPF1 recruitment to cytoplasmic mRNA decay foci in vivo, suggesting that SMG7 acts as an adaptor in targeting mRNAs associated with phosphorylated UPF1 for degradation. The 14-3-3 site of SMG7 is conserved in SMG5 and SMG6. These data also imply that the homologous human Est1 might have a 14-3-3 function at telomeres, and that phosphorylation events may be important for telomerase regulation.
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The line below this paragraph, {{ABSTRACT_PUBMED_15721257}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 15721257 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15721257}}
==About this Structure==
==About this Structure==
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[[Category: 14-3-3]]
[[Category: 14-3-3]]
[[Category: Alpha-helical repeat]]
[[Category: Alpha-helical repeat]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 16:03:37 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 23:26:54 2008''

Revision as of 20:26, 28 July 2008

Image:1ya0.png

Template:STRUCTURE 1ya0

Crystal structure of the N-terminal domain of human SMG7

Template:ABSTRACT PUBMED 15721257

About this Structure

1YA0 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

SMG7 is a 14-3-3-like adaptor in the nonsense-mediated mRNA decay pathway., Fukuhara N, Ebert J, Unterholzner L, Lindner D, Izaurralde E, Conti E, Mol Cell. 2005 Feb 18;17(4):537-47. PMID:15721257

Page seeded by OCA on Mon Jul 28 23:26:54 2008

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