2b8k

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[[Image:2b8k.gif|left|200px]]
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{{STRUCTURE_2b8k| PDB=2b8k | SCENE= }}
{{STRUCTURE_2b8k| PDB=2b8k | SCENE= }}
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'''12-subunit RNA Polymerase II'''
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===12-subunit RNA Polymerase II===
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==Overview==
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Macromolecular assemblies as large as RNA polymerase II (Pol II) can be phased by a few intrinsically bound Zn atoms, by using MAD experiments as described here. A phasing effectiveness of 570 aa/Zn is attained for Pol II. The resulting experimental, unbiased electron density map is of such quality that it confirms the existing crystallographic model and further reveals structural regions not shown by model phases, thus updating the Pol II model at three sites. The mechanistically important fork loop-1 element is observed to be ordered in the absence of nucleic acids, suggesting additional insights into the mechanisms that maintain the stability of the transcription ternary complex and allow its release. Furthermore, a computational experiment with simulated MAD data sets demonstrates that 1 Zn site is able to provide adequate experimental phase information for as many as 1100 amino acids of polypeptide, under the conditions of the current synchrotron and detector technologies.
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(as it appears on PubMed at http://www.pubmed.gov), where 16765890 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16765890}}
==About this Structure==
==About this Structure==
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[[Category: Transcription]]
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[[Category: Zinc]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 23:50:12 2008''

Revision as of 20:50, 28 July 2008

Image:2b8k.png

Template:STRUCTURE 2b8k

12-subunit RNA Polymerase II

Template:ABSTRACT PUBMED 16765890

About this Structure

2B8K is a Protein complex structure of sequences from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

Phasing RNA polymerase II using intrinsically bound Zn atoms: an updated structural model., Meyer PA, Ye P, Zhang M, Suh MH, Fu J, Structure. 2006 Jun;14(6):973-82. PMID:16765890

Page seeded by OCA on Mon Jul 28 23:50:12 2008

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