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230d

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{{STRUCTURE_230d| PDB=230d | SCENE= }}
{{STRUCTURE_230d| PDB=230d | SCENE= }}
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'''SOLUTION STRUCTURES OF UNIMOLECULAR QUADRUPLEXES FORMED BY OLIGONUCLEOTIDES CONTAINING OXYTRICHA TELOMERE REPEATS'''
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===SOLUTION STRUCTURES OF UNIMOLECULAR QUADRUPLEXES FORMED BY OLIGONUCLEOTIDES CONTAINING OXYTRICHA TELOMERE REPEATS===
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==Overview==
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BACKGROUND: Oligonucleotides containing the guanine-rich telomeric sequence of Oxytricha chromosomes (dT4G4) have previously been shown to form DNA quadruplexes comprising guanine quartets stabilized by cations. Two different structures have been reported for both d(G4T4G4) (Oxy1.5) and d(G4T4G4T4G4T4G4) (Oxy3.5). RESULTS: Here we present the solution structure of a uracil- and inosine-containing derivative of Oxy3.5, d(G4TUTUG4T4G4UUTTG3I) (Oxy3.5-U4128), determined using two-dimensional 1H and 31P NMR techniques. This oligonucleotide forms a unimolecular quadruplex that is very similar to the dimeric Oxy1.5 solution structure, in that it contains a loop spanning the diagonal of an end quartet. The groove widths, strand polarities, and positions of the syn bases along the G4 tracts and within the quartets are all as reported for Oxy1.5. The first and third pyrimidine tracts form parallel loops spanning a wide groove and a narrow groove respectively. CONCLUSIONS: Both Oxy3.5 and Oxy3.5-U(4)128 form unimolecular quadruplexes in solution with a diagonal central T4 loop. These results conflict with those reported for d(G4TUTUG4TTUUG4UUTTG4) in solution, in which the central loop spans a wide groove.
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(as it appears on PubMed at http://www.pubmed.gov), where 8590010 is the PubMed ID number.
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{{ABSTRACT_PUBMED_8590010}}
==About this Structure==
==About this Structure==
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=230D OCA].
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Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=230D OCA].
==Reference==
==Reference==
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[[Category: Oxytricha telomere repeat]]
[[Category: Oxytricha telomere repeat]]
[[Category: Quadruplex]]
[[Category: Quadruplex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 18:20:50 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 23:59:44 2008''

Revision as of 20:59, 28 July 2008

Image:230d.png

Template:STRUCTURE 230d

SOLUTION STRUCTURES OF UNIMOLECULAR QUADRUPLEXES FORMED BY OLIGONUCLEOTIDES CONTAINING OXYTRICHA TELOMERE REPEATS

Template:ABSTRACT PUBMED 8590010

About this Structure

Full experimental information is available from OCA.

Reference

Solution structures of unimolecular quadruplexes formed by oligonucleotides containing Oxytricha telomere repeats., Smith FW, Schultze P, Feigon J, Structure. 1995 Oct 15;3(10):997-1008. PMID:8590010

Page seeded by OCA on Mon Jul 28 23:59:44 2008

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