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1r2q

From Proteopedia

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[[Image:1r2q.gif|left|200px]]
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{{STRUCTURE_1r2q| PDB=1r2q | SCENE= }}
{{STRUCTURE_1r2q| PDB=1r2q | SCENE= }}
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'''Crystal Structure of Human Rab5a GTPase Domain at 1.05 A resolution'''
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===Crystal Structure of Human Rab5a GTPase Domain at 1.05 A resolution===
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==Overview==
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Rab5 is a GTPase that regulates early endosome fusion. Its GTPase domain crystal structure is reported here at 1.05 A resolution in complex with a GTP-analog molecule. It provides the highest resolution three-dimensional model so far obtained for proteins from the Ras-like GTPase family. This study allows extension of structural examination of the GTPase machinery as well as of high-resolution protein structures in general. For example, a buried water-molecule network was observed underneath the switch regions, which is consistent with the functional roles of these regions in the molecular-switching process. Furthermore, residues of multiple conformation and clustered distribution of anisotropic thermal motions of the protein molecule may have general implications for the function of Ras-like GTPases.
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(as it appears on PubMed at http://www.pubmed.gov), where 14684892 is the PubMed ID number.
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{{ABSTRACT_PUBMED_14684892}}
==About this Structure==
==About this Structure==
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[[Category: Gtpase]]
[[Category: Gtpase]]
[[Category: Rab]]
[[Category: Rab]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 00:01:18 2008''

Revision as of 21:01, 28 July 2008

Image:1r2q.png

Template:STRUCTURE 1r2q

Crystal Structure of Human Rab5a GTPase Domain at 1.05 A resolution

Template:ABSTRACT PUBMED 14684892

About this Structure

1R2Q is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Refinement of the structure of human Rab5a GTPase domain at 1.05 A resolution., Terzyan S, Zhu G, Li G, Zhang XC, Acta Crystallogr D Biol Crystallogr. 2004 Jan;60(Pt 1):54-60. Epub 2003, Dec 18. PMID:14684892

Page seeded by OCA on Tue Jul 29 00:01:18 2008

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