1rtj

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[[Image:1rtj.jpg|left|200px]]
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{{STRUCTURE_1rtj| PDB=1rtj | SCENE= }}
{{STRUCTURE_1rtj| PDB=1rtj | SCENE= }}
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'''MECHANISM OF INHIBITION OF HIV-1 REVERSE TRANSCRIPTASE BY NON-NUCLEOSIDE INHIBITORS'''
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===MECHANISM OF INHIBITION OF HIV-1 REVERSE TRANSCRIPTASE BY NON-NUCLEOSIDE INHIBITORS===
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==Overview==
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The structure of unliganded HIV-1 reverse transcriptase has been determined at 2.35 A resolution and refined to an R-factor of 0.219 (for all data) with good stereochemistry. The unliganded structure was produced by soaking out a weak binding non-nucleoside inhibitor, HEPT, from pregrown crystals. Comparison with the structures of four different RT and non-nucleoside inhibitor complexes reveals that only minor domain rearrangements occur, but there is a significant repositioning of a three-stranded beta-sheet in the p66 subunit (containing the catalytic aspartic acid residues 110, 185 and 186) with respect to the rest of the polymerase site. This suggests that NNIs inhibit RT by locking the polymerase active site in an inactive conformation, reminiscent of the conformation observed in the inactive p51 subunit.
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The line below this paragraph, {{ABSTRACT_PUBMED_7540935}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 7540935 is the PubMed ID number.
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{{ABSTRACT_PUBMED_7540935}}
==About this Structure==
==About this Structure==
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[[Category: Stuart, D.]]
[[Category: Stuart, D.]]
[[Category: Hiv-1 reverse transcriptase]]
[[Category: Hiv-1 reverse transcriptase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 07:53:20 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 00:11:52 2008''

Revision as of 21:11, 28 July 2008

Image:1rtj.png

Template:STRUCTURE 1rtj

MECHANISM OF INHIBITION OF HIV-1 REVERSE TRANSCRIPTASE BY NON-NUCLEOSIDE INHIBITORS

Template:ABSTRACT PUBMED 7540935

About this Structure

1RTJ is a Protein complex structure of sequences from Human immunodeficiency virus 1. Full crystallographic information is available from OCA.

Reference

Mechanism of inhibition of HIV-1 reverse transcriptase by non-nucleoside inhibitors., Esnouf R, Ren J, Ross C, Jones Y, Stammers D, Stuart D, Nat Struct Biol. 1995 Apr;2(4):303-8. PMID:7540935

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