This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1n26

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1n26.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1n26.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1n26| PDB=1n26 | SCENE= }}
{{STRUCTURE_1n26| PDB=1n26 | SCENE= }}
-
'''Crystal Structure of the extra-cellular domains of Human Interleukin-6 Receptor alpha chain'''
+
===Crystal Structure of the extra-cellular domains of Human Interleukin-6 Receptor alpha chain===
-
==Overview==
+
<!--
-
Dysregulated production of IL-6 and its receptor (IL-6R) are implicated in the pathogenesis of multiple myeloma, autoimmune diseases and prostate cancer. The IL-6R complex comprises two molecules each of IL-6, IL-6R, and the signaling molecule, gp130. Here, we report the x-ray structure (2.4 A) of the IL-6R ectodomains. The N-terminal strand of the Ig-like domain (D(1)) is disulfide-bonded to domain D(2), and domains D(2) and D(3), the cytokine-binding domain, are structurally similar to known cytokine-binding domains. The head-to-tail packing of two closely associated IL-6R molecules observed in the crystal may be representative of the configuration of the physiological dimer of IL-6R and provides new insight into the architecture of the IL-6R complex.
+
The line below this paragraph, {{ABSTRACT_PUBMED_12461182}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 12461182 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_12461182}}
==About this Structure==
==About this Structure==
Line 34: Line 38:
[[Category: Immunoglobulin domain]]
[[Category: Immunoglobulin domain]]
[[Category: Transmembrane]]
[[Category: Transmembrane]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 01:59:44 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 00:41:10 2008''

Revision as of 21:41, 28 July 2008

Template:STRUCTURE 1n26

Crystal Structure of the extra-cellular domains of Human Interleukin-6 Receptor alpha chain

Template:ABSTRACT PUBMED 12461182

About this Structure

1N26 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure of the extracellular domains of the human interleukin-6 receptor alpha -chain., Varghese JN, Moritz RL, Lou MZ, Van Donkelaar A, Ji H, Ivancic N, Branson KM, Hall NE, Simpson RJ, Proc Natl Acad Sci U S A. 2002 Dec 10;99(25):15959-64. Epub 2002 Dec 2. PMID:12461182

Page seeded by OCA on Tue Jul 29 00:41:10 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1n26"
Personal tools