2hvy

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:2hvy.gif|left|200px]]
+
{{Seed}}
 +
[[Image:2hvy.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_2hvy| PDB=2hvy | SCENE= }}
{{STRUCTURE_2hvy| PDB=2hvy | SCENE= }}
-
'''Crystal structure of an H/ACA box RNP from Pyrococcus furiosus'''
+
===Crystal structure of an H/ACA box RNP from Pyrococcus furiosus===
-
==Overview==
+
<!--
-
H/ACA ribonucleoprotein particles (RNPs) are a family of RNA pseudouridine synthases that specify modification sites through guide RNAs. They also participate in eukaryotic ribosomal RNA processing and are a component of vertebrate telomerases. Here we report the crystal structure, at 2.3 A resolution, of an entire archaeal H/ACA RNP consisting of proteins Cbf5, Nop10, Gar1 and L7ae, and a single-hairpin H/ACA RNA, revealing a modular organization of the complex. The RNA upper stem is bound to a composite surface formed by L7ae, Nop10 and Cbf5, and the RNA lower stem and ACA signature motif are bound to the PUA domain of Cbf5, thereby positioning middle guide sequences so that they are primed to pair with substrate RNA. Furthermore, Gar1 may regulate substrate loading and release. The structure rationalizes the consensus structure of H/ACA RNAs, suggests a functional role of each protein, and provides a framework for understanding the mechanism of RNA-guided pseudouridylation, as well as various cellular functions of H/ACA RNP.
+
The line below this paragraph, {{ABSTRACT_PUBMED_16943774}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 16943774 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_16943774}}
==About this Structure==
==About this Structure==
Line 27: Line 31:
[[Category: Pseudouridine synthase]]
[[Category: Pseudouridine synthase]]
[[Category: Rnp]]
[[Category: Rnp]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 06:46:40 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 00:53:12 2008''

Revision as of 21:53, 28 July 2008

Image:2hvy.png

Template:STRUCTURE 2hvy

Crystal structure of an H/ACA box RNP from Pyrococcus furiosus

Template:ABSTRACT PUBMED 16943774

About this Structure

2HVY is a Protein complex structure of sequences from Pyrococcus furiosus. Full crystallographic information is available from OCA.

Reference

Crystal structure of an H/ACA box ribonucleoprotein particle., Li L, Ye K, Nature. 2006 Sep 21;443(7109):302-7. Epub 2006 Aug 30. PMID:16943774

Page seeded by OCA on Tue Jul 29 00:53:12 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2hvy"
Personal tools