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2a0t

From Proteopedia

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{{STRUCTURE_2a0t| PDB=2a0t | SCENE= }}
{{STRUCTURE_2a0t| PDB=2a0t | SCENE= }}
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'''NMR structure of the FHA1 domain of Rad53 in complex with a biological relevant phosphopeptide derived from Madt1'''
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===NMR structure of the FHA1 domain of Rad53 in complex with a biological relevant phosphopeptide derived from Madt1===
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==Overview==
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Combinatorial library screens based on binding affinity may preferentially select ligands with ability for ionic interactions and miss the biologically relevant ligands that bind more weakly with predominantly hydrophobic interactions.
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The line below this paragraph, {{ABSTRACT_PUBMED_16231900}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 16231900 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16231900}}
==About this Structure==
==About this Structure==
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2A0T is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A0T OCA].
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2A0T is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A0T OCA].
==Reference==
==Reference==
FHA domain-ligand interactions: importance of integrating chemical and biological approaches., Mahajan A, Yuan C, Pike BL, Heierhorst J, Chang CF, Tsai MD, J Am Chem Soc. 2005 Oct 26;127(42):14572-3. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16231900 16231900]
FHA domain-ligand interactions: importance of integrating chemical and biological approaches., Mahajan A, Yuan C, Pike BL, Heierhorst J, Chang CF, Tsai MD, J Am Chem Soc. 2005 Oct 26;127(42):14572-3. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16231900 16231900]
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Solution structures of two FHA1-phosphothreonine peptide complexes provide insight into the structural basis of the ligand specificity of FHA1 from yeast Rad53., Yuan C, Yongkiettrakul S, Byeon IJ, Zhou S, Tsai MD, J Mol Biol. 2001 Nov 30;314(3):563-75. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11846567 11846567]
[[Category: Non-specific serine/threonine protein kinase]]
[[Category: Non-specific serine/threonine protein kinase]]
[[Category: Protein complex]]
[[Category: Protein complex]]
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[[Category: Phosphoprotein]]
[[Category: Phosphoprotein]]
[[Category: Phosphothreonine]]
[[Category: Phosphothreonine]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 00:55:05 2008''

Revision as of 21:55, 28 July 2008

Template:STRUCTURE 2a0t

NMR structure of the FHA1 domain of Rad53 in complex with a biological relevant phosphopeptide derived from Madt1

Template:ABSTRACT PUBMED 16231900

About this Structure

2A0T is a Protein complex structure of sequences from Saccharomyces cerevisiae. Full experimental information is available from OCA.

Reference

FHA domain-ligand interactions: importance of integrating chemical and biological approaches., Mahajan A, Yuan C, Pike BL, Heierhorst J, Chang CF, Tsai MD, J Am Chem Soc. 2005 Oct 26;127(42):14572-3. PMID:16231900

Solution structures of two FHA1-phosphothreonine peptide complexes provide insight into the structural basis of the ligand specificity of FHA1 from yeast Rad53., Yuan C, Yongkiettrakul S, Byeon IJ, Zhou S, Tsai MD, J Mol Biol. 2001 Nov 30;314(3):563-75. PMID:11846567

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